Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mesalamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.64 |
| ▸ | ALOX5 known ✓ | P09917 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | CASP1 | P29466 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | TNF | P01375 | 1/20 | 0.64 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mesalamine SCHEMBL10492977 | 0.96 | KDM4E (0.66) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Mesalamine SCHEMBL4332303 | 0.96 | KDM4E (0.71) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Mesalamine SCHEMBL15329060 | 0.96 | KDM4E (0.66) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Mesalamine SCHEMBL15329038 | 0.96 | KDM4E (0.66) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Aminosalicylic Acid SCHEMBL1457932 | 0.83 | KDM4E (0.92) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Mesalamine SCHEMBL9146031 | 0.83 | KDM4E (0.54) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Olsalazine SCHEMBL4096909 | 0.79 | MEN1 (0.66) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Aminosalicylic Acid SCHEMBL1477512 | 0.79 | KDM4E (0.92) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Aminosalicylic Acid SCHEMBL1047421 | 0.79 | KDM4E (0.92) | KDM4ETDP1POLBALDH1A1CYP3A4 | |
| Aminosalicylic Acid SCHEMBL688206 | 0.79 | KDM4E (1.00) | KDM4ETDP1POLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067867-B2 | Preparation of 5-aminosalicylic acid by gas phase catalytic carboxylation | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2015-06-30 | — | — | US | disclosed |
| US-20130281730-A1 | PREPARATION OF 5-AMINOSALICYLIC ACID BY GAS PHASE CATALYTIC CARBOXYLATION | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281730-A1 | PREPARATION OF 5-AMINOSALICYLIC ACID BY GAS PHASE CATALYTIC CARBOXYLATION | PTGES, PTGS1, PTGS2 | PTGS2 3/4885ALOX5 9/4885KDM4E 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.