SCHEMBL15329656

SCHEMBL15329656

Cc1ccc2c(=O)c(C=CC=O)coc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
MAPT P10636 4/20 0.50
ALDH1A1 P00352 4/20 0.50
KDM4E B2RXH2 1/20 0.50
HPGD P15428 1/20 0.50
HTT P42858 1/20 0.50
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
MAOA P21397 10/20 0.48
MAOB P27338 10/20 0.48
PTPN1 P18031 3/20 0.46
PTPN2 P17706 1/20 0.46
GAA P10253 1/20 0.45
NPC1 O15118 1/20 0.44
CYP1A2 P05177 1/20 0.44
THRB P10828 1/20 0.43
PTGS2 P35354 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15329654 1.00 CYP3A4 (0.52) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL29956322 0.84 PTPN1 (0.61) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL2556028 0.78 MAPT (0.57) MAPTALDH1A1KDM4EHPGDMEN1
SCHEMBL2556026 0.78 MAPT (0.57) MAPTALDH1A1KDM4EHPGDMEN1
SCHEMBL7600910 0.74 MAPT (0.50) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL29952420 0.72 ALDH1A1 (0.68) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL911098 0.72 ALDH1A1 (0.68) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL17876375 0.71 MAPT (0.47) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL2556734 0.71 MEN1 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19MAPT
SCHEMBL2556736 0.71 MEN1 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed