SCHEMBL15330604

SCHEMBL15330604

Cc1cc(C)c2[nH]c(-c3ccc(Cl)cc3)c(C=O)c2c1

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.40
ABCB1 P08183 1/20 0.38
BRD4 O60885 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
FFAR4 Q5NUL3 1/20 0.36
DHODH Q02127 1/20 0.36
PTGES O14684 1/20 0.36
ALOX5 P09917 1/20 0.36
PTGS2 P35354 2/20 0.35
TP53 P04637 1/20 0.35
LMNA P02545 1/20 0.35
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29951123 0.90 MAPT (0.42) MAPTABCB1BRD4SMN1; SMN2PTGS2
SCHEMBL2557465 0.86 MAPT (0.38) MAPTABCB1SMN1; SMN2LMNA
SCHEMBL15330956 0.86 APOL1 (0.38) BRD4PTGESALOX5PTGS2ALOX15
SCHEMBL29954645 0.86 TNKS2 (0.40) MAPTABCB1SMN1; SMN2FFAR4PTGS2
SCHEMBL2556848 0.85 ALOX5 (0.39) MAPTABCB1SMN1; SMN2PTGESALOX5
SCHEMBL15329748 0.84 ERN1 (0.40) MAPTABCB1SMN1; SMN2DHODHPTGS2
SCHEMBL29951627 0.84 MAPT (0.38) MAPTABCB1SMN1; SMN2PTGESALOX5
SCHEMBL5635400 0.82 TNKS (0.43) PTGESALOX5PTGS2
SCHEMBL29955457 0.82 SMN1; SMN2 (0.59) MAPTSMN1; SMN2LMNA
SCHEMBL29955733 0.81 ABCB1 (0.40) MAPTABCB1SMN1; SMN2PTGESALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed