Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 7/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Magnesium SCHEMBL30992114 | 0.98 | CDK8 (0.53) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| Quinoline SCHEMBL27994190 | 0.83 | AXL (0.51) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL4831501 | 0.78 | CDK8 (0.81) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL878796 | 0.77 | ULK1 (0.48) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23655689 | 0.77 | CDK8 (0.56) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3348675 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL294106 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL297772 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL294108 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL11968477 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2526 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4682148-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | AbbVie Ireland Unlimited Company (IE) | 2026-01-21 | — | — | EP | claimed |
| EP-4474383-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | AbbVie Ireland Unlimited Company (IE) | 2024-12-11 | — | — | EP | claimed |
| CN-118373820-A | Continuous preparation method and continuous synthesis device of 5-hydroxy-7-azaindole | 峰成医药科技(天津)有限公司 | 2024-07-23 | — | — | CN | claimed |
| CN-115057856-B | 3, 5-disubstituted-7-azaindole derivative and synthetic method and application thereof | 澳门科技大学 | 2024-04-02 | — | — | CN | claimed |
| CN-115141197-B | 3-aromatic heterocycle substituted phenyl derivative and preparation method and application thereof | 安徽医科大学 | 2024-03-26 | — | — | CN | claimed |
| CN-117126157-A | Preparation method of 5-hydroxy-7-azaindole | 舞阳威森生物医药有限公司 | 2023-11-28 | — | — | CN | claimed |
| CN-115991705-A | 3- (1H pyrrolo [2,3-b ] pyridin-5-yl) benzoyl derivatives, preparation and application thereof | 安徽医科大学 | 2023-04-21 | — | — | CN | claimed |
| US-20220315555-A1 | APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC. (US) | 2022-10-06 | — | — | US | claimed |
| CN-115141197-A | 3-aromatic heterocyclic substituted phenyl derivative and preparation method and application thereof | 安徽医科大学 | 2022-10-04 | — | — | CN | claimed |
| CN-115057856-A | 3, 5-disubstituted-7 azaindole derivative and synthesis method and application thereof | 澳门科技大学 | 2022-09-16 | — | — | CN | claimed |
| CN-101781298-A | Method for preparing 5-cyano-7-azaindole | ABA CHEMICALS SUZHOU LTD | 2010-07-21 | — | — | CN | claimed |
| CN-101607958-A | Quinazoline compound | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | CN | claimed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | claimed |
| US-20090156821-A1 | Quinazoline compounds | ASTRAZENECA AB | 2009-06-18 | — | — | US | claimed |
| US-7268230-B2 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2007-09-11 | — | — | US | claimed |
| US-20060270646-A1 | Jnk inhibitors | EISAI CO., LTD. (JP) | 2006-11-30 | — | — | US | claimed |
| CN-1625555-A | Quinazoline compounds | ASTRAZENECA AB (SE) | 2005-06-08 | — | — | CN | claimed |
| US-20050085465-A1 | Angiogenesis inhibitor; antiarthritic agents; psoriasis; anticancer agents | ASTRAZENECA AB (SE) | 2005-04-21 | — | — | US | claimed |
| EP-1474420-A1 | QUINAZOLINE COMPOUNDS | Astrazeneca AB (SE) | 2004-11-10 | — | — | EP | claimed |
| WO-2003064413-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | WO | claimed |