Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 6/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.51 |
| ▸ | AHR | P35869 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28838214 | 0.83 | AXL (0.51) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL16746926 | 0.80 | RIPK1 (0.71) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL410298 | 0.80 | RIPK1 (0.71) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL4831501 | 0.78 | CDK8 (0.81) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL7996669 | 0.77 | ULK1 (0.48) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23655689 | 0.77 | CDK8 (0.56) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13854143 | 0.76 | NUDT1 (0.56) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL294106 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL297772 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3348675 | 0.75 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 695 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114736204-A | Preparation method of pexidaltinib structural analogue and application of pexidaltinib structural analogue in tumor resistance | 湖北工业大学 | 2022-07-12 | — | — | CN | claimed |
| CN-113816956-A | Synthesis method of pexidaltinib | 湖北工业大学 | 2021-12-21 | — | — | CN | claimed |
| CN-104478909-B | The synthesis technique of heterocyclic boronic acids compounds | 上海泰坦科技股份有限公司 | 2017-01-04 | — | — | CN | claimed |
| CN-106279156-A | A kind of synthetic method of 5 chlorine 7 azaindoles | 叶芳 | 2017-01-04 | — | — | CN | claimed |
| US-20150284388-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED | 2015-10-08 | — | — | US | claimed |
| US-20150099884-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED | 2015-04-09 | — | — | US | claimed |
| US-20140309421-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-16 | — | — | US | claimed |
| EP-2729465-A2 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | Vertex Pharmaceuticals Incorporated (US) | 2014-05-14 | — | — | EP | claimed |
| US-8513414-B2 | Processes and intermediates for producing azaindoles | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-20 | — | — | US | claimed |
| US-20130102782-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-25 | — | — | US | claimed |
| WO-2013006634-A9 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-03-21 | — | — | WO | claimed |
| WO-2013006634-A2 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | WO | claimed |
| CN-101402635-B | Process for producing 5-chlorine-7-aza indole | ABA CHEMICALS SHANGHAI LTD | 2011-01-12 | — | — | CN | claimed |
| CN-101402635-A | Process for producing 5-chlorine-7-aza indole | ABA CHEMICALS SHANGHAI LTD (CN) | 2009-04-08 | — | — | CN | claimed |
| CN-116496219-B | Six-membered and five-membered heterocyclic compound, and pharmaceutical composition and application thereof | 东南大学 | 2026-05-15 | — | — | CN | disclosed |
| US-12559489-B2 | Antagonistic small molecule compound having toll-like receptor 7/9 inhibitory function | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2026-02-24 | — | — | US | disclosed |
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | Psylo Pty Ltd (AU) | 2025-11-27 | — | — | US | disclosed |
| US-20060003968-A1 | Azaindoles useful as inhibitors of rock and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2006-01-05 | — | — | US | disclosed |
| WO-2005103050-A2 | AZAINDOLES USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-11-03 | — | — | WO | disclosed |
| WO-2005095400-A1 | AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099884-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | JAK2, JAK3, JAK1 | CDK8 32/4885AXL 1344/4885PIK3CD 139/4885 |
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | HTR2C, HTR2A, HTR6 | CDK8 1147/4885AXL 2342/4885PIK3CD 1300/4885 |
| US-20140309421-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | JAK2, JAK3, JAK1 | CDK8 32/4885AXL 1344/4885PIK3CD 139/4885 |
| US-20060003968-A1 | Azaindoles useful as inhibitors of rock and other protein kinases | ROCK2, ROCK1, TNK2 | CDK8 280/4885AXL 2432/4885PIK3CD 197/4885 |
| US-20130102782-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | JAK2, JAK3, JAK1 | CDK8 32/4885AXL 1344/4885PIK3CD 139/4885 |
| US-12559489-B2 | Antagonistic small molecule compound having toll-like receptor 7/9 inhibitory function | TLR9, TLR7, TLR1 | CDK8 2670/4885AXL 1069/4885PIK3CD 957/4885 |
| US-20150284388-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | JAK2, JAK3, JAK1 | CDK8 32/4885AXL 1344/4885PIK3CD 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.