Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28838214 | 0.83 | AXL (0.51) | AXLNUDT1ALDH1A1CDK8MET | |
| SCHEMBL153413 | 0.83 | CDK8 (0.55) | AXLNUDT1CDK8PIK3CDPIK3CA | |
| Quinoline SCHEMBL28218277 | 0.81 | ALDH1A1 (0.63) | ALDH1A1CYP1A2CYP2C19HTTNR4A2 | |
| Quinoline SCHEMBL20292966 | 0.81 | AXL (0.78) | AXLNUDT1ALDH1A1CDK8CYP1A2 | |
| Magnesium SCHEMBL30992114 | 0.81 | CDK8 (0.53) | AXLNUDT1CDK8PIK3CDPIK3CA | |
| Quinoline SCHEMBL28859524 | 0.80 | AXL (0.75) | AXLNUDT1ALDH1A1CDK8CYP1A2 | |
| Quinoline SCHEMBL27705544 | 0.78 | AHR (0.62) | AXLNUDT1ALDH1A1CYP1A2CYP2C19 | |
| Quinoline SCHEMBL28046361 | 0.75 | AHR (0.62) | AXLNUDT1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL857921 | 0.73 | AXL (0.50) | AXLNUDT1CDK8METPIK3CD | |
| SCHEMBL271715 | 0.72 | BIRC5 (0.59) | ALDH1A1CYP1A2PIK3CDPIK3CAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107987076-A | A kind of synthetic method of 5- bromo-7-azaindoles | 中钢集团鞍山热能研究院有限公司 | 2018-05-04 | — | — | CN | claimed |
| CN-105622605-B | A kind of synthetic method of the azaindole of 5 bromine 7 | 苏州艾缇克药物化学有限公司 | 2017-10-13 | — | — | CN | claimed |
| CN-105461718-A | Synthesis process of 5-bromo-7-azaindole | SUZHOU RYAN PHARMACHEM TECH CO LTD | 2016-04-06 | — | — | CN | claimed |
| CN-109776527-A | A kind of synthetic method of 5- bromo-7-azaindole | 药雅科技(上海)有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109081840-A | A kind of preparation method of 5- bromo-7-azaindole | 郑州大学第附属医院 | 2018-12-25 | — | — | CN | disclosed |
| CN-107987076-A | A kind of synthetic method of 5- bromo-7-azaindoles | 中钢集团鞍山热能研究院有限公司 | 2018-05-04 | — | — | CN | disclosed |
| CN-105622605-B | A kind of synthetic method of the azaindole of 5 bromine 7 | 苏州艾缇克药物化学有限公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-106432228-A | 4-oximido-1-piperidyl fragment containing 7-azaindolin-2-one compound and preparation method therefor | 浙江司太立制药股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106397436-A | 5-bromo-7-azaindoline-2-one compounds and preparation method thereof | 浙江司太立制药股份有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-105622605-A | Synthesis method of 5-bromo-7-azaindole | ITIC MEDCHEM CO LTD | 2016-06-01 | — | — | CN | disclosed |
| CN-105461718-A | Synthesis process of 5-bromo-7-azaindole | SUZHOU RYAN PHARMACHEM TECH CO LTD | 2016-04-06 | — | — | CN | disclosed |
| CN-104387384-A | Synthetic process of 5-bromo-7-azaindole | SHANGHAI HUMAN BIOTECHNOLOGY CO LTD | 2015-03-04 | — | — | CN | disclosed |