Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16526493 | 0.89 | LMNA (0.41) | FAAHLMNALPAR1TSHRCASP2 | |
| SCHEMBL15369063 | 0.85 | FAAH (0.49) | FAAHLPAR1DNM1CASP2ALDH1A1 | |
| SCHEMBL12248456 | 0.85 | PAOX (0.46) | FAAHLPAR1TSHRDNM1PAOX | |
| SCHEMBL25700613 | 0.84 | LMNA (0.39) | LMNALPAR1TSHRCASP2ALDH1A1 | |
| SCHEMBL14878513 | 0.83 | FAAH (0.40) | FAAHLMNALPAR1TSHRDNM1 | |
| SCHEMBL25700311 | 0.81 | ALDH1A1 (0.43) | FAAHLMNALPAR1TSHRCASP2 | |
| SCHEMBL8975691 | 0.81 | LMNA (0.46) | FAAHLMNALPAR1TSHRCASP2 | |
| SCHEMBL811258 | 0.80 | CASP2 (0.50) | FAAHLPAR1TSHRDNM1PAOX | |
| SCHEMBL13292124 | 0.80 | CASP2 (0.50) | FAAHLPAR1TSHRDNM1PAOX | |
| SCHEMBL8978061 | 0.80 | CASP2 (0.50) | FAAHLPAR1TSHRDNM1PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865677-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130281685-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2013-10-24 | — | — | US | disclosed |