Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804583 | 1.00 | KDM4E (0.62) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL5664524 | 0.95 | KDM4E (0.58) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL28419062 | 0.91 | KDM4E (0.59) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL28498302 | 0.89 | KDM4E (0.52) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL27468792 | 0.87 | KDM4E (0.56) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL28433422 | 0.85 | HTR2C (0.61) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL367247 | 0.82 | ALDH1A1 (0.48) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL28900079 | 0.82 | KDM4E (0.50) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL28842848 | 0.80 | KDM4E (0.44) | KDM4ELMNAGABRR1HTR2CALDH1A1 | |
| SCHEMBL20658776 | 0.80 | KDM4E (0.48) | KDM4ELMNAGABRR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108472280-A | Compounds and methods for treating or preventing hematologic cancers | 布罗德研究所股份有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-107921288-A | The targeting conjugate of KSP inhibitor | 拜耳医药股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| EP-2657346-B1 | METHOD FOR DETECTING CANCER CELL | ARKRAY INC (JP) | 2017-08-23 | — | — | EP | disclosed |
| US-9645154-B2 | Method for detecting cancer cell | ARKRAY, INC. (JP) | 2017-05-09 | — | — | US | disclosed |
| US-20130288273-A1 | Method for Detecting Cancer Cell | ARKRAY, INC. (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2657346-A1 | METHOD FOR DETECTING CANCER CELL | Arkray, Inc. (JP) | 2013-10-30 | — | — | EP | disclosed |