Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL25239253 | 0.93 | NOS3 (0.36) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| Glycine SCHEMBL8588130 | 0.90 | GLRA1 (0.42) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| SCHEMBL352049 | 0.90 | SLC1A5 (0.43) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| SCHEMBL3502798 | 0.90 | SLC1A5 (0.43) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| Glycine SCHEMBL1548291 | 0.85 | SLC1A5 (0.38) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| SCHEMBL4752999 | 0.85 | SLC1A5 (0.40) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| SCHEMBL12500454 | 0.85 | SLC1A5 (0.40) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| Aspartic Acid SCHEMBL20394531 | 0.84 | GRIK1 (0.43) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Serine SCHEMBL18191257 | 0.84 | SLC1A5 (0.41) | GRIK1GRIK2GRM1GRM2SLC1A5 | |
| Serine SCHEMBL9702742 | 0.84 | SLC1A5 (0.41) | GRIK1GRIK2GRM1GRM2SLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9597412-B2 | Injectable delivery system for heparan-binding growth factors | UNIVERSITY OF DELAWARE (US) | 2017-03-21 | — | — | US | disclosed |
| US-20140005111-A1 | INJECTABLE DELIVERY SYSTEM FOR HEPARAN-BINDING GROWTH FACTORS | UNIVERSITY OF DELAWARE (US) | 2014-01-02 | — | — | US | disclosed |