Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL15399013 | 0.93 | GRIK1 (0.38) | NOS3NOS1NOS2SLC1A5GRIK1 | |
| Glycine SCHEMBL8588130 | 0.84 | GLRA1 (0.42) | NOS3NOS1NOS2ALOX15BLM | |
| SCHEMBL3502798 | 0.84 | SLC1A5 (0.43) | NOS3NOS1NOS2ALOX15BLM | |
| SCHEMBL352049 | 0.84 | SLC1A5 (0.43) | NOS3NOS1NOS2ALOX15BLM | |
| SCHEMBL9393776 | 0.83 | NOS3 (0.36) | NOS3NOS1NOS2ALOX15BLM | |
| Asparagine SCHEMBL7459478 | 0.82 | ALOX15 (0.45) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL366069 | 0.80 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL10011961 | 0.80 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7998953 | 0.80 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL366070 | 0.80 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024049682-A2 | PROTEINS FOR CROSS-LINKING BIOPOLYMERS | ZYMERGEN INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| WO-2023102551-A2 | FUNGAL PROTEASES, TREATED COMPOSITIONS, AND USES THEREOF | SHARED-X LLC (US) | 2023-06-08 | — | — | WO | disclosed |