Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15415417 | 0.92 | CYP11B2 (0.40) | PDE10ACYP11B2PIK3CBJAK2JAK3 | |
| SCHEMBL15416560 | 0.86 | CYP11B2 (0.41) | CYP11B2PIK3CBCCR3MCHR1KCNH2 | |
| SCHEMBL16763611 | 0.84 | CYP11B2 (0.47) | CYP11B2CCR3MCHR1KCNH2EP300 | |
| SCHEMBL15416360 | 0.84 | CYP11B2 (0.47) | CYP11B2CCR3MCHR1KCNH2EP300 | |
| SCHEMBL19470911 | 0.83 | CYP11B2 (0.46) | PDE10ACYP11B2JAK2JAK3CCR3 | |
| SCHEMBL24165560 | 0.83 | CYP11B2 (0.46) | CYP11B2CCR3MCHR1KCNH2LRRK2 | |
| SCHEMBL18807889 | 0.82 | CYP11B2 (0.43) | CYP11B2CCR3MCHR1KCNH2ALDH1A1 | |
| SCHEMBL16512912 | 0.79 | CCR3 (0.48) | CYP11B2CCR3MCHR1KCNH2 | |
| SCHEMBL16763370 | 0.79 | CYP11B2 (0.43) | CYP11B2JAK2CCR3MCHR1KCNH2 | |
| SCHEMBL22495117 | 0.79 | FPR2 (0.47) | CYP11B2ALDH1A1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728220-B1 | PHARMACEUTICAL COMPOUNDS | REVIRAL LTD (GB) | 2022-01-05 | — | — | EP | disclosed |
| US-11141406-B2 | Pharmaceutical compounds | ReViral Limited (GB) | 2021-10-12 | — | — | US | disclosed |
| CN-107108557-B | Spirocyclic indolines for the treatment and prophylaxis of Respiratory Syncytial Virus (RSV) infection | 瑞威有限公司 | 2020-11-10 | — | — | CN | disclosed |
| EP-3728220-A1 | PHARMACEUTICAL COMPOUNDS | Reviral Limited (GB) | 2020-10-28 | — | — | EP | disclosed |
| US-20200316030-A1 | PHARMACEUTICAL COMPOUNDS | SILICON VALLEY BANK | 2020-10-08 | — | — | US | disclosed |
| EP-3204375-B1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | REVIRAL LTD (GB) | 2019-02-13 | — | — | EP | disclosed |
| US-10106539-B2 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) | ReViral Limited (GB) | 2018-10-23 | — | — | US | disclosed |
| US-20170305908-A1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | ReViral Limited (GB) | 2017-10-26 | — | — | US | disclosed |
| EP-2872502-B1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2016-08-24 | — | — | EP | disclosed |
| US-20160200741-A1 | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2016-07-14 | — | — | US | disclosed |
| US-9206191-B2 | Indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-20150158879-A1 | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2015-06-11 | — | — | US | disclosed |
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11141406-B2 | Pharmaceutical compounds | CBR3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1 | PDE10A 1713/4885CYP11B2 375/4885PIK3CB 4581/4885 |
| US-20170305908-A1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | NR3C2, SAV1, ACE2 | PDE10A 4824/4885CYP11B2 874/4885PIK3CB 4750/4885 |
| US-20200316030-A1 | PHARMACEUTICAL COMPOUNDS | CBR3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1 | PDE10A 2068/4885CYP11B2 334/4885PIK3CB 4508/4885 |
| US-20150158879-A1 | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | ADORA3, ADORA1, BRS3 | PDE10A 4238/4885CYP11B2 526/4885PIK3CB 3660/4885 |
| US-20160200741-A1 | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | ADORA3, ADORA1, BRS3 | PDE10A 4238/4885CYP11B2 526/4885PIK3CB 3660/4885 |
| US-10106539-B2 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) | SPTBN1, NR3C2, SPNS2 | PDE10A 4848/4885CYP11B2 748/4885PIK3CB 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.