Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542265 | 0.80 | GRIN2D (0.43) | ADRB2DRD2DRD1DRD4DRD3 | |
| SCHEMBL2180109 | 0.73 | GRIN2D (0.43) | SCN9ALMNA | |
| SCHEMBL2179672 | 0.73 | LMNA (0.41) | ALOX5SCN9ALMNAFFAR1PDE4A | |
| SCHEMBL3434604 | 0.70 | ADRB2 (0.45) | ADRB2DRD2DRD1DRD4DRD3 | |
| SCHEMBL8901961 | 0.63 | CYP2D6 (0.58) | IDO1 | |
| SCHEMBL90811 | 0.63 | IDO1 (0.61) | IDO1LMNA | |
| SCHEMBL11419578 | 0.63 | HTR1A (0.58) | IDO1ADRB2DRD2DRD1DRD4 | |
| SCHEMBL1541828 | 0.62 | SMN1; SMN2 (0.47) | SCN9APDE4D | |
| SCHEMBL8827585 | 0.62 | ABCB1 (0.35) | — | |
| SCHEMBL8827624 | 0.62 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303850-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | Bionomics Limited (AU) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009149508-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2009-12-17 | — | — | WO | disclosed |