Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386404 | 0.87 | SMN1; SMN2 (0.41) | ADRB2DRD2DRD1DRD4DRD3 | |
| SCHEMBL3762438 | 0.75 | ALOX5 (0.50) | ALOX5SCN9AAKR1B10AKR1B1TRPV1 | |
| SCHEMBL1541828 | 0.75 | SMN1; SMN2 (0.47) | SCN9APDE4D | |
| SCHEMBL1542014 | 0.72 | PDE4D (0.48) | ALOX5SCN9AAKR1B10AKR1B1TRPV1 | |
| SCHEMBL14835642 | 0.71 | ALOX5 (0.51) | ALOX5SCN9ANPC1RAB9A | |
| SCHEMBL13339111 | 0.71 | MAPT (0.48) | — | |
| SCHEMBL1541630 | 0.70 | IDO1 (0.40) | ADRB2DRD2DRD1DRD4DRD3 | |
| SCHEMBL1541608 | 0.70 | PDE4D (0.51) | ALOX5SCN9APDE4APDE4BPDE4C | |
| SCHEMBL11419578 | 0.70 | HTR1A (0.58) | ADRB2DRD2DRD1DRD4DRD3 | |
| SCHEMBL7896500 | 0.69 | TUBB4A (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197832-A1 | NOVEL ARYL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | Bionomics Limited (AU) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009043117-A1 | NOVEL ARYL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2009-04-09 | — | — | WO | disclosed |