Sugi Predict

Sugi Predict / Compounds / SCHEMBL15420213

SCHEMBL15420213

SCHEMBL15420213

CCS(=O)(=O)N[C@H]1CCCO[C@@H]1COc1ccc(-c2ccc(Cl)cn2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ GRIA2 P42262 1/20 0.37
▸ RAB9A P51151 7/20 0.37
▸ NPC1 O15118 5/20 0.37
▸ TNF P01375 1/20 0.36
▸ SMN1; SMN2 Q16637 6/20 0.35
▸ ALDH1A1 P00352 7/20 0.35
▸ HPGD P15428 3/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ KDM4E B2RXH2 3/20 0.34
▸ HTT P42858 2/20 0.34
▸ POLB P06746 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ MCHR1 Q99705 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ GALR3 O60755 1/20 0.33
▸ CYP11B1 P15538 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15420610 0.91 GRIA2 (0.38) LMNAMAPK1GRIA2RAB9ANPC1
SCHEMBL15420523 0.89 NPC1 (0.44) LMNAMAPK1RAB9ANPC1SMN1; SMN2
SCHEMBL15420021 0.89 RAB9A (0.37) LMNAMAPK1GRIA2RAB9ANPC1
SCHEMBL21795673 0.89 RAB9A (0.37) LMNAMAPK1GRIA2RAB9ANPC1
SCHEMBL15420407 0.89 GRIA2 (0.41) LMNAMAPK1GRIA2RAB9ANPC1
SCHEMBL15420096 0.88 KDM4E (0.45) LMNAMAPK1RAB9ANPC1TNF
SCHEMBL15420570 0.84 P2RX3 (0.38) LMNAMAPK1RAB9ANPC1SMN1; SMN2
SCHEMBL15420142 0.82 NPC1 (0.41) LMNAMAPK1RAB9ANPC1SMN1; SMN2
SCHEMBL15420711 0.82 RAB9A (0.37) LMNAMAPK1RAB9ANPC1SMN1; SMN2
SCHEMBL15419836 0.81 LMNA (0.38) LMNAMAPK1RAB9ANPC1TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694472-B1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2020-03-11 — — EP disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20070161771-A1 SYNTHESIS OF ELASTOMERIC CARBORANE-SILOXANES BY HYDROSILATION REACTIONS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2007-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF GRIN2A, GRIN2B, SLC1A2 LMNA 4794/4885MAPK1 1793/4885GRIA2 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.