SCHEMBL15423957

SCHEMBL15423957

O=C1CNC2(CCN(c3ccncc3)CC2)N1Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.43
CYP2D6 P10635 5/20 0.43
CYP2C9 P11712 4/20 0.43
HIF1A Q16665 2/20 0.43
MAPK1 P28482 2/20 0.43
ALDH1A1 P00352 2/20 0.43
TSHR P16473 2/20 0.43
CYP3A4 P08684 5/20 0.43
CYP2C19 P33261 4/20 0.43
CYP1A2 P05177 2/20 0.43
OPRL1 P41146 1/20 0.41
USP2 O75604 2/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
HSD17B10 Q99714 1/20 0.40
GSK3A P49840 1/20 0.40
GSK3B P49841 1/20 0.40
HRH1 P35367 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15423954 0.91 DRD4 (0.46) CYP2D6ALDH1A1TSHROPRL1USP2
Simufilam SCHEMBL12627054 0.80 MC4R (0.46) MAPK1ALDH1A1LMNAMAPTHTT
Simufilam SCHEMBL22361802 0.79 MC4R (0.45) MAPK1ALDH1A1LMNAMAPTHTT
Simufilam SCHEMBL22361808 0.79 MC4R (0.45) MAPK1ALDH1A1LMNAMAPTHTT
SCHEMBL12656278 0.79 GSK3A (0.42) CYP2C9HIF1AALDH1A1TSHRCYP2C19
SCHEMBL15426339 0.79 OPRL1 (0.37) SMN1; SMN2CYP2D6CYP2C9ALDH1A1TSHR
Simufilam SCHEMBL22361805 0.78 MC4R (0.44) MAPK1ALDH1A1LMNAMAPTHTT
SCHEMBL15426043 0.78 ALDH1A1 (0.43) SMN1; SMN2CYP2D6ALDH1A1TSHRCYP3A4
SCHEMBL12627083 0.76 KMT2A (0.48) CYP2D6CYP2C9HIF1AALDH1A1TSHR
SCHEMBL24106950 0.75 OPRD1 (0.46) CYP2D6MAPK1ALDH1A1TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014012054-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATENT PAIN THERAPEUTICS, INC. (US) 2014-01-16 WO disclosed
WO-2014011917-A2 A METHOD OF INHIBITING TAU PHOSPHORYLATION PAIN THERAPEUTICS, INC. (US) 2014-01-16 WO disclosed