Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Simufilam SCHEMBL12627054 | 0.87 | MC4R (0.46) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| Simufilam SCHEMBL22361808 | 0.86 | MC4R (0.45) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| Simufilam SCHEMBL22361802 | 0.86 | MC4R (0.45) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| Simufilam SCHEMBL22361805 | 0.84 | MC4R (0.44) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL15423954 | 0.84 | DRD4 (0.46) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL12627083 | 0.82 | KMT2A (0.48) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL24106950 | 0.81 | OPRD1 (0.46) | GSK3AGSK3BALDH1A1KDM4ELMNA | |
| SCHEMBL12661184 | 0.80 | OPRL1 (0.47) | ALDH1A1KDM4ELMNAHTTNPSR1 | |
| SCHEMBL24106959 | 0.80 | RIPK1 (0.39) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL15423957 | 0.79 | SMN1; SMN2 (0.43) | GSK3AGSK3BALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105481-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | PAIN THERAPEUTICS | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105481-A1 | FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC | FLNA, FLNB, OPRK1 | GSK3A 3191/4885GSK3B 3552/4885KMT2A 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.