Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180100 | 0.89 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1ALOX15TSHR | |
| SCHEMBL1542460 | 0.85 | KCNA3 (0.30) | — | |
| SCHEMBL1542264 | 0.84 | MEN1 (0.37) | ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1542536 | 0.84 | ADORA2A (0.31) | LMNAALDH1A1KDM4E | |
| SCHEMBL1542572 | 0.83 | MEN1 (0.33) | ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL2179188 | 0.78 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1ALOX15TSHR | |
| SCHEMBL2178695 | 0.76 | NAMPT (0.34) | SMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL1542365 | 0.76 | P4HB (0.34) | KMT2AMEN1 | |
| SCHEMBL1542325 | 0.75 | MC4R (0.30) | — | |
| SCHEMBL13573974 | 0.74 | PTGER4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303850-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | Bionomics Limited (AU) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009149508-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2009-12-17 | — | — | WO | disclosed |