Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179289 | 0.89 | MEN1 (0.39) | MEN1KMT2ASIGMAR1HTR1AHTR2A | |
| SCHEMBL1542460 | 0.86 | KCNA3 (0.30) | — | |
| SCHEMBL1542528 | 0.84 | LMNA (0.41) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1542536 | 0.83 | ADORA2A (0.31) | HTR2AALDH1A1KDM4EADORA2AADORA1 | |
| SCHEMBL12409106 | 0.82 | SLC6A2 (0.36) | SIGMAR1HTR1AHTR2AALDH1A1 | |
| SCHEMBL2178490 | 0.82 | ALDH1A1 (0.36) | MEN1KMT2AHTR2AALDH1A1 | |
| SCHEMBL12409122 | 0.82 | MEN1 (0.38) | MEN1KMT2ASIGMAR1HTR1AHTR2A | |
| SCHEMBL2180251 | 0.82 | SIGMAR1 (0.39) | MEN1KMT2ASIGMAR1HTR1AHTR2A | |
| SCHEMBL12409118 | 0.82 | MEN1 (0.38) | MEN1KMT2ASIGMAR1HTR1AHTR2A | |
| SCHEMBL1542572 | 0.82 | MEN1 (0.33) | MEN1KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303850-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | Bionomics Limited (AU) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009149508-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2009-12-17 | — | — | WO | disclosed |