Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179535 | 0.89 | MEN1 (0.35) | MEN1ALDH1A1POLBGAAKMT2A | |
| SCHEMBL1542460 | 0.87 | KCNA3 (0.30) | — | |
| SCHEMBL1542536 | 0.84 | ADORA2A (0.31) | ALDH1A1HTR2C | |
| SCHEMBL1542528 | 0.83 | LMNA (0.41) | MEN1ALDH1A1POLBKMT2A | |
| SCHEMBL1542264 | 0.82 | MEN1 (0.37) | MEN1ALDH1A1KMT2ARAB9A | |
| SCHEMBL2177504 | 0.81 | MEN1 (0.34) | MEN1ALDH1A1POLBGAAKMT2A | |
| SCHEMBL2179404 | 0.77 | MEN1 (0.35) | MEN1ALDH1A1POLBGAAKMT2A | |
| SCHEMBL1542365 | 0.76 | P4HB (0.34) | MEN1KMT2A | |
| SCHEMBL2178824 | 0.75 | KCNA3 (0.32) | — | |
| SCHEMBL12409102 | 0.75 | METAP2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303850-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | Bionomics Limited (AU) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009149508-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2009-12-17 | — | — | WO | disclosed |