SCHEMBL15426494

SCHEMBL15426494

Cc1cnc2c(c1)nc(-c1ccc([N+](=O)[O-])cc1F)n2C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ S1PR4 O95977 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ AMY1A P0DUB6 1/20 0.38
▸ MAPT P10636 3/20 0.38
▸ ALDH1A1 P00352 3/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ PKM P14618 1/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.38
▸ HPGD P15428 1/20 0.37
▸ NPBWR1 P48145 1/20 0.37
▸ KAT2B Q92831 1/20 0.37
▸ DYRK3 O43781 1/20 0.36
▸ ABL1 P00519 1/20 0.36
▸ CDK1 P06493 1/20 0.36
▸ CSF1R P07333 1/20 0.36
▸ MET P08581 1/20 0.36
▸ PDGFRB P09619 1/20 0.36
▸ PHKG2 P15735 1/20 0.36
▸ CDK2 P24941 1/20 0.36
▸ MARK3 P27448 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10281065 0.87 POLB (0.41) S1PR4POLBAMY1AMAPTALDH1A1
SCHEMBL15426465 0.77 HSD11B1 (0.41) NPC1
SCHEMBL15426498 0.77 AMY1A (0.43) POLBAMY1AMAPTALDH1A1RAB9A
SCHEMBL15426486 0.77 HSD11B1 (0.47) POLB
SCHEMBL15426502 0.77 AKT1 (0.33) POLBRAB9APKMNPC1SMN1; SMN2
SCHEMBL15426510 0.76 BRD4 (0.40) ALDH1A1CDK1CDK5L3MBTL1
SCHEMBL10248903 0.75 POLB (0.38) POLBSMN1; SMN2
SCHEMBL10249125 0.74 AKT1 (0.32) —
SCHEMBL15426501 0.73 HSD11B1 (0.42) CDK2DYRK1ALRRK2
SCHEMBL18951169 0.72 BRD4 (0.39) MAPTALDH1A1RAB9AHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 — — US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 — — US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 — — US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 S1PR4 3292/4885POLB 4715/4885AMY1A 1081/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 S1PR4 3305/4885POLB 4737/4885AMY1A 1272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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