SCHEMBL15426502

SCHEMBL15426502

CCSc1ccc(-c2nc3cc(C)cnc3n2C)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ AKT1 P31749 2/20 0.33
▸ AKT2 P31751 2/20 0.33
▸ POLB P06746 1/20 0.33
▸ BRD4 O60885 1/20 0.33
▸ GRIN1 Q05586 6/20 0.32
▸ GRIN2B Q13224 6/20 0.32
▸ ALOX5AP P20292 1/20 0.31
▸ FEN1 P39748 1/20 0.31
▸ PDE10A Q9Y233 4/20 0.31
▸ OXTR P30559 1/20 0.31
▸ GRM5 P41594 1/20 0.30
▸ PDE2A O00408 1/20 0.30
▸ NPC1 O15118 1/20 0.30
▸ PKM P14618 1/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10280808 0.87 POLB (0.48) POLBPDE10APDE2A
SCHEMBL15426382 0.81 CYP11B1 (0.34) AKT1AKT2POLBBRD4GRIN1
SCHEMBL15426388 0.78 TNKS (0.37) AKT1AKT2BRD4PDE10APDE2A
SCHEMBL15426465 0.77 HSD11B1 (0.41) AKT1AKT2BRD4PDE10APDE2A
SCHEMBL15412355 0.77 AKT1 (0.39) AKT1AKT2POLBBRD4ALOX5AP
SCHEMBL15426498 0.77 AMY1A (0.43) POLBPDE10APDE2ANPC1RAB9A
SCHEMBL15426486 0.77 HSD11B1 (0.47) POLBALOX5APFEN1PDE10APDE2A
SCHEMBL15426452 0.77 AKT1 (0.33) AKT1AKT2POLBBRD4PDE10A
SCHEMBL15426494 0.77 S1PR4 (0.38) POLBNPC1PKMRAB9ASMN1; SMN2
SCHEMBL15426411 0.76 POLB (0.41) AKT1AKT2POLBBRD4GRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 — — US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 — — US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 — — US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 AKT1 1919/4885AKT2 2509/4885POLB 4715/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 AKT1 1808/4885AKT2 2400/4885POLB 4737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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