Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CCR1 | P32246 | 3/20 | 0.40 |
| ▸ | CCR8 | P51685 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18300448 | 0.88 | PARG (0.38) | CYP3A4CCR1CCR8MAPTPARG | |
| SCHEMBL28969092 | 0.85 | CYP3A4 (0.56) | CYP3A4CCR1CCR8MAPTPARG | |
| SCHEMBL30353608 | 0.85 | CYP3A4 (0.56) | CYP3A4CCR1CCR8MAPTPARG | |
| SCHEMBL25369992 | 0.85 | TERT (0.41) | CYP3A4CCR1CCR8MAPTPARG | |
| SCHEMBL15428069 | 0.85 | PARG (0.37) | CYP3A4CCR1CCR8MAPTPARG | |
| SCHEMBL7214223 | 0.85 | CYP3A4 (0.38) | CYP3A4MAPTPARGLMNAAPEX1 | |
| SCHEMBL1205625 | 0.82 | TNF (0.47) | CYP3A4MAPTLMNAMAPK1PMP22 | |
| SCHEMBL28551219 | 0.81 | ALDH1A1 (0.46) | CYP3A4MAPTPARGLMNAAPEX1 | |
| SCHEMBL15124778 | 0.80 | LMNA (0.44) | CYP3A4CCR1CCR8MAPTPARG | |
| SCHEMBL30576347 | 0.80 | LMNA (0.44) | CYP3A4CCR1CCR8MAPTPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100534986-C | Method for preparing derivative of 1,4 - dichloro isoquinoline category | UNIV ZHEJIANG POLYTECHNIC (CN) | 2009-09-02 | — | — | CN | claimed |
| CN-101092395-A | Method for preparing derivative of 1,4 - dichloro isoquinoline category | UNIV ZHEJIANG POLYTECHNIC (CN) | 2007-12-26 | — | — | CN | claimed |
| US-9837622-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-9837622-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-20150263297-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| US-20150263297-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| WO-2014008982-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-01-16 | — | — | WO | disclosed |
| CN-100534986-C | Method for preparing derivative of 1,4 - dichloro isoquinoline category | UNIV ZHEJIANG POLYTECHNIC (CN) | 2009-09-02 | — | — | CN | disclosed |
| CN-101092395-A | Method for preparing derivative of 1,4 - dichloro isoquinoline category | UNIV ZHEJIANG POLYTECHNIC (CN) | 2007-12-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150263297-A1 | Metal Complexes | SOD1, AP1M1, AP3M1 | CYP3A4 2252/4885CCR1 2964/4885CCR8 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.