Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATIC | P31939 | 1/20 | 0.48 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.46 |
| ▸ | ST6GAL1 | P15907 | 7/20 | 0.43 |
| ▸ | ST3GAL1 | Q11201 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ST3GAL3 | Q11203 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | OSBP | P22059 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.37 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16506704 | 1.00 | ATIC (0.48) | ATICNPC1L1ST6GAL1ST3GAL1PTPN1 | |
| SCHEMBL2448736 | 0.91 | NPC1L1 (0.55) | ATICNPC1L1ST6GAL1ST3GAL1PTPN1 | |
| SCHEMBL1542632 | 0.83 | USP2 (0.61) | NPC1L1ST6GAL1ST3GAL1CYP17A1USP2 | |
| SCHEMBL12436829 | 0.82 | OSBP (0.59) | NPC1L1USP2LMNAABCB1OSBP | |
| Olesoxime SCHEMBL18870340 | 0.77 | ATIC (0.66) | ATICNPC1L1PTPN1CYP17A1KDM4E | |
| Olesoxime SCHEMBL19236075 | 0.77 | ATIC (0.66) | ATICNPC1L1PTPN1CYP17A1KDM4E | |
| Olesoxime SCHEMBL19668128 | 0.77 | ATIC (0.66) | ATICNPC1L1PTPN1CYP17A1KDM4E | |
| Olesoxime SCHEMBL19668134 | 0.77 | ATIC (0.66) | ATICNPC1L1PTPN1CYP17A1KDM4E | |
| Olesoxime SCHEMBL19668133 | 0.77 | ATIC (0.66) | ATICNPC1L1PTPN1CYP17A1KDM4E | |
| Olesoxime SCHEMBL1010553 | 0.77 | ATIC (0.66) | ATICNPC1L1PTPN1CYP17A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307438-B1 | CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2018-03-07 | — | — | EP | claimed |
| US-20160339041-A1 | LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE | TROPHOS (FR) | 2016-11-24 | — | — | US | claimed |
| US-9447140-B2 | Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method | TROPHOS (FR) | 2016-09-20 | — | — | US | claimed |
| US-20150056269-A1 | LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE | TROPHOS (FR) | 2015-02-26 | — | — | US | claimed |
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2011-09-15 | — | — | US | claimed |
| EP-2307438-B1 | CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2018-03-07 | — | — | EP | disclosed |
| US-20160339041-A1 | LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE | TROPHOS (FR) | 2016-11-24 | — | — | US | disclosed |
| US-9447140-B2 | Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method | TROPHOS (FR) | 2016-09-20 | — | — | US | disclosed |
| US-20150056269-A1 | LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE | TROPHOS (FR) | 2015-02-26 | — | — | US | disclosed |
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2011-09-15 | — | — | US | disclosed |
| EP-2307438-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | Trophos (FR) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012904-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | NR1H3, NR1H2, CYP27A1 | ATIC 4622/4885NPC1L1 22/4885ST6GAL1 3055/4885 |
| US-20160339041-A1 | LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE | LIPA, NPC1L1, CETP | ATIC 4085/4885NPC1L1 2/4885ST6GAL1 185/4885 |
| US-20150056269-A1 | LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE | LIPA, NPC1L1, CETP | ATIC 4085/4885NPC1L1 2/4885ST6GAL1 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.