Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.44 |
| ▸ | OSBP | P22059 | 3/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.42 |
| ▸ | ST3GAL1 | Q11201 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12436829 | 0.89 | OSBP (0.59) | USP2NPC1L1NR1H3DHCR24OSBP | |
| SCHEMBL2448736 | 0.87 | NPC1L1 (0.55) | USP2NPC1L1LMNACYP17A1ST6GAL1 | |
| SCHEMBL17693794 | 0.83 | OSBP (0.60) | USP2NPC1L1NR1H3DHCR24OSBP | |
| SCHEMBL1542841 | 0.83 | ATIC (0.48) | USP2NPC1L1OSBPRORCLMNA | |
| SCHEMBL16506704 | 0.83 | ATIC (0.48) | USP2NPC1L1OSBPRORCLMNA | |
| SCHEMBL17696316 | 0.80 | OSBP (0.63) | USP2NPC1L1NR1H3DHCR24OSBP | |
| SCHEMBL4142848 | 0.77 | POLA1 (0.54) | USP2NPC1L1NR1H3DHCR24OSBP | |
| Cholest-5-En-3-One SCHEMBL20597931 | 0.77 | USP2 (1.00) | USP2CTSDNR1H3SRD5A1OSBP | |
| Cholest-5-En-3-One SCHEMBL13255128 | 0.77 | USP2 (1.00) | USP2CTSDNR1H3SRD5A1OSBP | |
| Cholest-5-En-3-One SCHEMBL15482076 | 0.77 | USP2 (1.00) | USP2CTSDNR1H3SRD5A1OSBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307438-B1 | CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2018-03-07 | — | — | EP | disclosed |
| US-9447140-B2 | Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method | TROPHOS (FR) | 2016-09-20 | — | — | US | disclosed |
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2011-09-15 | — | — | US | disclosed |
| EP-2307438-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | Trophos (FR) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012904-A2 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | TROPHOS (FR) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224180-A1 | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND PREPARATION METHOD | NR1H3, NR1H2, CYP27A1 | USP2 2006/4885CTSD 2967/4885NPC1L1 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.