Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242512 | 0.92 | HDAC1 (0.69) | HDAC1HPGDSMN1; SMN2HDAC2HDAC3 | |
| SCHEMBL14188465 | 0.82 | HDAC1 (0.86) | HDAC1SMN1; SMN2HDAC3ALDH1A1KMT2A | |
| SCHEMBL5048895 | 0.74 | HDAC1 (1.00) | HDAC1SMN1; SMN2HDAC2HDAC3HDAC10 | |
| SCHEMBL1732448 | 0.72 | HDAC1 (0.60) | HDAC1HPGDHDAC2HDAC3HDAC10 | |
| SCHEMBL7476725 | 0.72 | HDAC1 (0.56) | HDAC1HPGDSMN1; SMN2HDAC2HDAC3 | |
| SCHEMBL3812243 | 0.70 | HDAC1 (0.64) | HDAC1SMN1; SMN2HDAC2HDAC3HDAC10 | |
| SCHEMBL1521002 | 0.70 | RAB9A (0.71) | HDAC1SMN1; SMN2HDAC2HDAC3HDAC10 | |
| SCHEMBL4896115 | 0.68 | HDAC1 (0.60) | HDAC1SMN1; SMN2HDAC2HDAC3HDAC10 | |
| SCHEMBL13352155 | 0.68 | ALDH1A1 (0.71) | HDAC1HPGDSMN1; SMN2HDAC2ALDH1A1 | |
| SCHEMBL3812238 | 0.67 | HDAC1 (0.59) | HDAC1SMN1; SMN2HDAC2HDAC3HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | HDAC1 1/4885HPGD 348/4885SMN1; SMN2 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.