SCHEMBL15433233

SCHEMBL15433233

CC/C(F)=C(\F)c1ccc(-c2ccc(-c3cc(F)c(CF)c(F)c3)cc2)cc1

nearest known ligand 0.32

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.32
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ERN1 O75460 4/20 0.31
FASN P49327 1/20 0.31
MAPT P10636 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MGLL Q99685 1/20 0.31
ANPEP P15144 1/20 0.30
CHKA P35790 1/20 0.30
CYP17A1 P05093 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP19A1 P11511 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15433182 0.85 ANPEP (0.40) KIF11RXRARXRBKDM4ELMNA
SCHEMBL15433383 0.85 ANPEP (0.40) KIF11RXRARXRBKDM4ELMNA
SCHEMBL15433538 0.79 RARB (0.38) RXRARXRBMAPTANPEPCYP17A1
SCHEMBL15433225 0.77 KIF11 (0.35) KIF11ERN1FASN
SCHEMBL15433179 0.76 RARB (0.36) KIF11KDM4ELMNAHSD17B10MAPT
SCHEMBL15433170 0.76 RARB (0.36) KIF11KDM4ELMNAHSD17B10MAPT
SCHEMBL15433387 0.76 RARB (0.36) KIF11KDM4ELMNAHSD17B10MAPT
SCHEMBL15433497 0.76 KIF11 (0.38) KIF11RXRARXRBCYP17A1CYP11B1
SCHEMBL15433181 0.75 RARB (0.40) FASNMAPTANPEPCYP3A4
SCHEMBL15433215 0.75 KIF11 (0.39) KIF11RXRARXRBKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed