Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428934 | 0.86 | NTRK1 (0.39) | BRD4MAPTLOXL2NTRK1NTRK2 | |
| SCHEMBL298911 | 0.82 | PLAU (0.44) | PLAUFGFR3FGFR1FGFR2MAPT | |
| SCHEMBL10046375 | 0.82 | PLAU (0.42) | BRD4PLAUFGFR3FGFR1FGFR2 | |
| SCHEMBL18900876 | 0.81 | PLAU (0.40) | PLAULOXL2 | |
| SCHEMBL15433747 | 0.80 | CYP19A1 (0.36) | ALPL | |
| SCHEMBL10015189 | 0.73 | BRD4 (0.39) | BRD4FGFR3FGFR1FGFR2MAPT | |
| SCHEMBL7900338 | 0.71 | HTR6 (0.38) | MAPT | |
| SCHEMBL288425 | 0.70 | SYK (0.35) | KDR | |
| SCHEMBL13929793 | 0.70 | PLAU (0.45) | BRD4PLAUFGFR3FGFR1FGFR2 | |
| SCHEMBL13929789 | 0.70 | PLAU (0.45) | BRD4PLAUFGFR3FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427434-B1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |
| US-8633320-B2 | Process for preparing bromo-substituted quinolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-21 | — | — | US | disclosed |