Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CDK1 | P06493 | 3/20 | 0.30 |
| ▸ | CDK2 | P24941 | 3/20 | 0.30 |
| ▸ | KDR | P35968 | 3/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18900876 | 0.72 | PLAU (0.40) | CYP19A1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL15433747 | 0.71 | CYP19A1 (0.36) | SYKLMNACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL15433735 | 0.70 | BRD4 (0.43) | KDR | |
| SCHEMBL7906969 | 0.69 | KDM4E (0.42) | LMNAGAARXFP1POLBALDH1A1 | |
| SCHEMBL9890977 | 0.65 | TYR (0.39) | LMNAGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL15578481 | 0.64 | TYR (0.42) | LMNAGAARXFP1ALDH1A1HSD17B10 | |
| SCHEMBL7906417 | 0.64 | KCNQ1 (0.37) | LMNAGAAPOLBALDH1A1KDM4E | |
| SCHEMBL12732039 | 0.63 | TYR (0.38) | LMNAGAARXFP1ALDH1A1HSD17B10 | |
| SCHEMBL7909715 | 0.62 | HTR6 (0.39) | LMNAGAARXFP1ALDH1A1CYP19A1 | |
| SCHEMBL12863750 | 0.62 | TYR (0.38) | LMNAGAARXFP1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427434-B1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |
| US-8633320-B2 | Process for preparing bromo-substituted quinolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-21 | — | — | US | disclosed |
| US-20120165534-A1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| EP-2427434-A1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | Boehringer Ingelheim International GmbH (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129451-A1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165534-A1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | HCCS, CYP3A7, ABL1 | SYK 3994/4885TSHR 1906/4885LMNA 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.