Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2308076 | 0.78 | TSHR (0.39) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10430438 | 0.76 | P2RX7 (0.41) | TSHRALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL25043764 | 0.76 | NAPRT (0.41) | TSHRALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6578328 | 0.76 | BACE1 (0.47) | TSHRALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL6589447 | 0.76 | TRIM24 (0.52) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8763290 | 0.75 | ALDH1A1 (0.57) | TSHRALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL30527294 | 0.75 | ALDH1A1 (0.57) | TSHRALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL18856198 | 0.74 | PABPC1 (0.43) | TSHRALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1939410 | 0.74 | GAA (0.50) | TSHRALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL29876843 | 0.74 | GAA (0.50) | TSHRALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687511-A1 | Pyridinone derivatives as tissue transglutaminase inhibitors | Zedira GmbH (DE) | 2014-01-22 | — | — | EP | disclosed |