Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 5/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15441969 | 0.89 | SLC7A5 (0.57) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| SCHEMBL31009751 | 0.89 | SLC7A5 (0.57) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| SCHEMBL15441968 | 0.89 | SLC7A5 (0.57) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL30999653 | 0.88 | NOS3 (0.56) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL20680181 | 0.88 | NOS3 (0.56) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL20703400 | 0.88 | NOS3 (0.56) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| SCHEMBL12718972 | 0.85 | SLC7A5 (0.49) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| SCHEMBL879316 | 0.85 | SLC7A5 (0.49) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| SCHEMBL8823287 | 0.85 | ALDH1A1 (0.44) | ALDH1A1GAAHSD17B10NOS3NOS1 | |
| SCHEMBL31753168 | 0.84 | SLC7A5 (0.42) | ALDH1A1GAAHSD17B10NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118726-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | SARCODE BIOSCIENCE INC. (US) | 2018-05-03 | — | — | US | disclosed |
| US-9708303-B2 | LFA-1 inhibitor and methods of preparation and polymorph thereof | SARCODE BIOSCIENCE INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150336939-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | SARCODE BIOSCIENCE INC. (US) | 2015-11-26 | — | — | US | disclosed |
| US-9085553-B2 | LFA-1 inhibitor and methods of preparation and polymorph thereof | SARcode Bioscience, Inc. (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140031387-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | SARCODE BIOSCIENCE INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031387-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | ITGB1, ITGA1, VCAM1 | ALDH1A1 62/4885GAA 490/4885HSD17B10 3420/4885 |
| US-20150336939-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | ITGB1, ITGA1, VCAM1 | ALDH1A1 62/4885GAA 490/4885HSD17B10 3420/4885 |
| US-20180118726-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | ITGB1, ITGA1, VCAM1 | ALDH1A1 62/4885GAA 490/4885HSD17B10 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.