Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19281546 | 0.81 | HPGD (0.40) | GAATSHRHTTALDH1A1KDM4E | |
| SCHEMBL17725768 | 0.81 | GAA (0.40) | GAATSHRALDH1A1KDM4ECYP1A2 | |
| SCHEMBL13739818 | 0.81 | CYP11B2 (0.55) | ALDH1A1HPGDMEN1KMT2ACYP11B2 | |
| SCHEMBL1545084 | 0.81 | GAA (0.46) | GAARXFP1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL26971202 | 0.78 | CYP3A4 (0.43) | GAARXFP1TSHRCYP3A4ALDH1A1 | |
| SCHEMBL5332912 | 0.77 | GAA (0.40) | GAATSHRCYP3A4HTTALDH1A1 | |
| SCHEMBL1104432 | 0.77 | NPSR1 (0.44) | GAATSHRCYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL1544457 | 0.76 | GAA (0.48) | GAARXFP1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL2895724 | 0.76 | GAA (0.45) | GAARXFP1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL1544760 | 0.76 | GAA (0.45) | GAARXFP1CTDSP1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11856955-B2 | Binary compositions as disruptors of Orco-mediated odorant sensing | VANDERBILT UNIVERSITY (US) | 2024-01-02 | — | — | US | disclosed |
| US-11856955-B2 | Binary compositions as disruptors of Orco-mediated odorant sensing | VANDERBILT UNIVERSITY (US) | 2024-01-02 | — | — | US | disclosed |
| US-20200390099-A1 | BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING | UNIV VANDERBILT (US) | 2020-12-17 | — | — | US | disclosed |
| US-10791739-B2 | Binary compositions as disruptors of orco-mediated odorant sensing | VANDERBILT UNIVERSITY (US) | 2020-10-06 | — | — | US | disclosed |
| US-20180192651-A1 | THERMAL VOLATILIZATION OF ORCO AGONISTS | VANDERBILT UNIVERSITY | 2018-07-12 | — | — | US | disclosed |
| US-20180192651-A1 | THERMAL VOLATILIZATION OF ORCO AGONISTS | VANDERBILT UNIVERSITY | 2018-07-12 | — | — | US | disclosed |
| US-20180092359-A1 | BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING | VANDERBILT UNIVERSITY | 2018-04-05 | — | — | US | disclosed |
| US-20180092359-A1 | BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING | VANDERBILT UNIVERSITY | 2018-04-05 | — | — | US | disclosed |
| WO-2017011466-A1 | THERMAL VOLATILIZATION OF ORCO AGONISTS | ZWIEBEL LAURENCE J (US) | 2017-01-19 | — | — | WO | disclosed |
| WO-2016154471-A1 | BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING | VANDERBILT UNIVERSITY (US) | 2016-09-29 | — | — | WO | disclosed |
| CN-1894241-A | \"1, 2, 4\" oxadiazoles as modulators of metabotropic glutamate receptor-5 | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20060122397-A1 | Exhibiting an activity at metabotropic glutamate receptors (mGluRs), especially at the mGluR5 receptor; neurological disorders, psychiatric disorders, acute and chronic pain | ASTRAZENECA AB (SE) | 2006-06-08 | — | — | US | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |
| US-20060004021-A1 | Tetrazole compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB | 2006-01-05 | — | — | US | disclosed |
| US-20050272779-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |
| EP-1529045-A2 | NEW COMPOUNDS | Astra Zeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| US-20040152699-A1 | Compounds | ASTRAZENECA AND NPS PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | disclosed |
| WO-2004014881-A2 | '1,2,4'OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRA ZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11856955-B2 | Binary compositions as disruptors of Orco-mediated odorant sensing | OR51E2, OR10J3, ORC3 | GAA 4564/4885RXFP1 1637/4885CTDSP1 3820/4885 |
| US-20040152699-A1 | Compounds | SDHA, CYP11B2, CYP11B1 | GAA 217/4885RXFP1 2093/4885CTDSP1 3660/4885 |
| US-20060122397-A1 | Exhibiting an activity at metabotropic glutamate receptors (mGluRs), especially at the mGluR5 receptor; neurological disorders, psychiatric disorders, acute and chronic pain | GRM5, GRIK5, GRM1 | GAA 2576/4885RXFP1 530/4885CTDSP1 3902/4885 |
| US-20060004021-A1 | Tetrazole compounds and their use as metabotropic glutamate receptor antagonists | GRM1, GRM3, GRM4 | GAA 3102/4885RXFP1 225/4885CTDSP1 1956/4885 |
| US-20050272779-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | GRM5, GRIK5, GRM2 | GAA 1542/4885RXFP1 717/4885CTDSP1 3541/4885 |
| US-20180192651-A1 | THERMAL VOLATILIZATION OF ORCO AGONISTS | OR51E2, OR10J3, TRPA1 | GAA 4303/4885RXFP1 479/4885CTDSP1 4549/4885 |
| US-20180092359-A1 | BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING | OR51E2, OR10J3, ORC3 | GAA 4521/4885RXFP1 1543/4885CTDSP1 3897/4885 |
| US-20200390099-A1 | BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING | OR51E2, OR10J3, ORC3 | GAA 4564/4885RXFP1 1637/4885CTDSP1 3820/4885 |
| US-10791739-B2 | Binary compositions as disruptors of orco-mediated odorant sensing | OR51E2, OR10J3, ORC3 | GAA 4521/4885RXFP1 1543/4885CTDSP1 3897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.