Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.76 |
| ▸ | DRD2 | P14416 | 10/20 | 0.76 |
| ▸ | HTR2A | P28223 | 10/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.75 |
| ▸ | HTR2C | P28335 | 4/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.75 |
| ▸ | HRH1 | P35367 | 4/20 | 0.75 |
| ▸ | HTR6 | P50406 | 4/20 | 0.75 |
| ▸ | DRD3 | P35462 | 3/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545073 | 0.89 | HTR1A (0.68) | HTR1ADRD2HTR2AHRH3KCNH2 | |
| SCHEMBL5995122 | 0.88 | HTR1A (0.67) | HTR1ADRD2HTR2AHRH3 | |
| Anisole SCHEMBL3645349 | 0.88 | DRD2 (0.63) | HTR1ADRD2HTR2AKCNH2HTR2C | |
| SCHEMBL7355139 | 0.88 | ACHE (0.68) | HTR1ADRD2HTR2AHRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL1545933 | 0.87 | HTR1A (0.66) | HTR1ADRD2HTR2AHRH3 | |
| SCHEMBL28774559 | 0.87 | HTR2A (0.80) | HTR1ADRD2HTR2AHRH3KCNH2 | |
| Alcohol SCHEMBL8713382 | 0.87 | HTR1A (0.69) | HTR1ADRD2HTR2AHRH3KCNH2 | |
| SCHEMBL28774561 | 0.87 | HTR1A (1.00) | HTR1ADRD2HTR2AHRH3KCNH2 | |
| Methane SCHEMBL7348385 | 0.86 | HTR1A (0.65) | HTR1ADRD2HTR2AHRH3KCNH2 | |
| SCHEMBL28774558 | 0.86 | HTR1A (1.00) | HTR1ADRD2HTR2AHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39198-E1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics | AVENTIS PHARMACEUTICALS INC. (US) | 2006-07-18 | — | — | US | claimed |
| US-5364866-A | Side effect reduction | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-11-15 | — | — | US | claimed |
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | claimed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | claimed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | claimed |
| EP-2311824-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | Aventis Pharmaceuticals Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| US-RE39265-E1 | Heteroarylpiperidines, and their use as antipsychotics and analgetics | AVENTIS PHARMACEUTICALS INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-RE39198-E1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics | AVENTIS PHARMACEUTICALS INC. (US) | 2006-07-18 | — | — | US | disclosed |
| US-6420390-B1 | ANALGESIC AGENTS | AVENTIS PHARMACEUTICALS INC. | 2002-07-16 | — | — | US | disclosed |
| US-RE37729-E1 | 4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility | AVENTIS PHARMACEUTICALS INC. | 2002-06-04 | — | — | US | disclosed |
| US-RE37478-E1 | COMPOUNDS WITH HETEROCYCLIC AMINO COMPOUNDS | AVENTIS PHARMACEUTICALS, INC. | 2001-12-18 | — | — | US | disclosed |
| EP-1110954-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | Aventis Pharmaceuticals Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
| US-5550130-A | ANTIPSYCHOTIC AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0402644-B1 | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1995011680-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-05-04 | — | — | WO | disclosed |
| US-5364866-A | Side effect reduction | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0402644-A1 | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |