Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 19/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 18/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 17/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71724 | 0.85 | NPSR1 (0.57) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL15463710 | 0.85 | OPRL1 (0.62) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2951072 | 0.84 | NPSR1 (0.56) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL23666448 | 0.82 | OPRM1 (0.57) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL16119812 | 0.78 | OPRM1 (0.64) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL13939174 | 0.74 | OPRL1 (0.65) | OPRL1OPRM1OPRK1OPRD1CYP2D6 | |
| SCHEMBL10047375 | 0.74 | NPSR1 (0.61) | OPRL1OPRM1OPRK1OPRD1CYP3A4 | |
| SCHEMBL15463922 | 0.73 | OPRL1 (0.47) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL2707046 | 0.73 | LMNA (0.63) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL303920 | 0.73 | LMNA (0.63) | OPRL1OPRM1OPRK1OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103649075-B | Isosorbide-5-Nitrae-dihydropyridine-3,5-dicarboxylate derivatives and preparation and application thereof | XUANZHU PHARMA CO.,LTD. (CN) | 2016-05-25 | — | — | CN | disclosed |
| US-9198902-B2 | 1,4-dihydropyridine-3,5-dicarboxylate derivatives and preparation and use thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2015-12-01 | — | — | US | disclosed |
| US-9198902-B2 | 1,4-dihydropyridine-3,5-dicarboxylate derivatives and preparation and use thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2015-12-01 | — | — | US | disclosed |
| US-9198902-B2 | 1,4-dihydropyridine-3,5-dicarboxylate derivatives and preparation and use thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2015-12-01 | — | — | US | disclosed |
| EP-2703398-A1 | 1,4-DIHYDROPYRIDINE -3,5-DICARBOXYLATE DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Xuanzhu Pharma Co., Ltd. (CN) | 2014-03-05 | — | — | EP | disclosed |
| EP-2703398-A1 | 1,4-DIHYDROPYRIDINE -3,5-DICARBOXYLATE DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Xuanzhu Pharma Co., Ltd. (CN) | 2014-03-05 | — | — | EP | disclosed |
| US-20140045896-A1 | 1,4-dihydropyridine-3,5-dicarboxylate Derivatives And Preparation And Use Thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2014-02-13 | — | — | US | disclosed |
| US-20140045896-A1 | 1,4-dihydropyridine-3,5-dicarboxylate Derivatives And Preparation And Use Thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2014-02-13 | — | — | US | disclosed |
| US-20140045896-A1 | 1,4-dihydropyridine-3,5-dicarboxylate Derivatives And Preparation And Use Thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045896-A1 | 1,4-dihydropyridine-3,5-dicarboxylate Derivatives And Preparation And Use Thereof | PKD1, REN, GLS | OPRL1 2323/4885OPRM1 1214/4885OPRK1 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.