Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | LDLR | P01130 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676747 | 0.76 | CYP11B1 (0.50) | CRBNLDLRPCSK9MAOAMAOB | |
| SCHEMBL15208245 | 0.75 | CRBN (0.44) | CRBNLDLRPCSK9MAOAMAOB | |
| SCHEMBL6294273 | 0.75 | FGFR1 (0.46) | CRBNLDLRPCSK9MAOBHPGDS | |
| SCHEMBL27989478 | 0.73 | CYP11B1 (0.49) | CRBNLDLRPCSK9CYP11B1CYP11B2 | |
| SCHEMBL19953049 | 0.72 | CYP11B1 (0.58) | CRBNLDLRPCSK9CYP11B1CYP11B2 | |
| SCHEMBL11394015 | 0.72 | CRBN (0.48) | CRBNLDLRPCSK9MAOAMAOB | |
| SCHEMBL11384012 | 0.72 | CYP11B1 (0.59) | CRBNCYP11B1CYP11B2CYP1A2HSP90AA1 | |
| SCHEMBL15209053 | 0.71 | LDLR (0.43) | CRBNLDLRPCSK9MAOAMAOB | |
| SCHEMBL27870946 | 0.71 | CRBN (0.43) | CRBNLDLRPCSK9MAOAMAOB | |
| SCHEMBL6291219 | 0.70 | PTGS2 (0.58) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079876-B2 | Imidazole derivatives and preparation method and use thereof | BEIJING ORBIEPHARM CO., LTD. (CN) | 2015-07-14 | — | — | US | disclosed |
| US-20140045901-A2 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045901-A2 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | PTGIS, PTGS1, PTGS2 | CRBN 2953/4885LDLR 4731/4885PCSK9 2025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.