Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291171 | 0.86 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1MAPK14CRBNMAPK13 | |
| SCHEMBL6294332 | 0.85 | MAPK14 (0.54) | HSP90AA1HSP90AB1MAPK14MAPK13MAPK12 | |
| SCHEMBL12676747 | 0.83 | CYP11B1 (0.50) | FGFR1HSP90AA1HSP90AB1MAPK14CRBN | |
| SCHEMBL6291235 | 0.80 | PTGS2 (0.59) | PTGS2IDO1PTGS1 | |
| SCHEMBL15209053 | 0.78 | LDLR (0.43) | FGFR1CRBNLDLRPCSK9PTGS2 | |
| SCHEMBL28534427 | 0.76 | MAPT (0.50) | FGFR1HSP90AA1HSP90AB1MAPK14CRBN | |
| SCHEMBL15464625 | 0.75 | CRBN (0.43) | HSP90AA1HSP90AB1MAPK14CRBNLDLR | |
| SCHEMBL27989478 | 0.73 | CYP11B1 (0.49) | HSP90AA1HSP90AB1CRBNLDLRPCSK9 | |
| SCHEMBL13790977 | 0.73 | MEN1 (0.49) | FGFR1 | |
| SCHEMBL19953049 | 0.72 | CYP11B1 (0.58) | FGFR1HSP90AA1HSP90AB1CRBNLDLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838476-B1 | Cyclooxygenase inhibitors; anticancer agents | J. URIACH & CIA, SA (ES) | 2005-01-04 | — | — | US | disclosed |
| EP-1122243-B1 | NOVEL IMIDAZOLES WITH ANTI-INFLAMMATORY ACTIVITY | URIACH Y COMPANIA S A J (ES) | 2004-09-08 | — | — | EP | disclosed |
| EP-1122243-A1 | NOVEL IMIDAZOLES WITH ANTI-INFLAMMATORY ACTIVITY | J. URIACH & CIA. S.A. (ES) | 2001-08-08 | — | — | EP | disclosed |