Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286488 | 0.89 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1KCNN4HPGDMEN1 | |
| SCHEMBL930673 | 0.88 | SLC37A4 (0.37) | HSP90AA1HSP90AB1KCNN4HPGDMEN1 | |
| SCHEMBL930691 | 0.88 | MEN1 (0.36) | HSP90AA1HSP90AB1KCNN4HPGDMEN1 | |
| SCHEMBL931234 | 0.87 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1KCNN4HPGDMEN1 | |
| SCHEMBL931758 | 0.81 | HCRTR1 (0.38) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL930519 | 0.81 | ALDH1A1 (0.40) | HSP90AA1HSP90AB1MEN1KMT2AGAA | |
| SCHEMBL8931074 | 0.79 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1HPGDMEN1KMT2A | |
| SCHEMBL1305613 | 0.77 | GAA (0.39) | HSP90AA1HSP90AB1HPGDMEN1KMT2A | |
| SCHEMBL13639233 | 0.73 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1HPGDMEN1KMT2A | |
| SCHEMBL15468252 | 0.73 | TUBB4A (0.40) | HSP90AA1HSP90AB1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648104-B2 | Method for treating proliferative disorders associated with mutations in c-Met | SYNTA PHARMACEUTICALS CORP. (US) | 2014-02-11 | — | — | US | disclosed |