Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.49 |
| ▸ | CDC42BPB | Q9Y5S2 | 6/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14649086 | 0.79 | MAP3K7 (0.56) | MAP3K7TAB1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL17032328 | 0.77 | AKT1 (0.42) | HSP90AB1ROCK2ROCK1LRRK2IRAK4 | |
| SCHEMBL19185358 | 0.77 | IRAK4 (0.41) | MAP3K7TAB1ROCK1LRRK2IRAK4 | |
| Toyocamycin Aglycone SCHEMBL7698538 | 0.77 | MAP3K7 (0.54) | MAP3K7TAB1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL154683 | 0.76 | CHUK (0.61) | MAP3K7TAB1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL17401156 | 0.75 | MAP3K7 (0.56) | MAP3K7TAB1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL26719943 | 0.74 | ROCK2 (0.61) | ROCK2ROCK1CDC42BPBCDC42BPALRRK2 | |
| SCHEMBL14670863 | 0.72 | MAP3K7 (0.52) | MAP3K7TAB1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL12590787 | 0.71 | CHUK (0.48) | MAP3K7TAB1HSP90AB1ROCK2ROCK1 | |
| SCHEMBL19185382 | 0.71 | MAP3K7 (0.41) | MAP3K7TAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718815-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-08-01 | — | — | US | disclosed |