Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646176 | 0.87 | POLB (0.51) | POLBPDE5ASMN1; SMN2TSHRMAPT | |
| SCHEMBL992901 | 0.84 | PKM (0.66) | POLBSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL17749304 | 0.81 | ALOX15 (0.66) | POLBPDE5ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL6055083 | 0.80 | VCAM1 (0.69) | SMN1; SMN2KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL1844612 | 0.73 | MAPT (0.74) | POLBSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL1460166 | 0.72 | L3MBTL1 (0.67) | POLBSMN1; SMN2KMT2AMEN1USP2 | |
| SCHEMBL3936569 | 0.71 | POLB (1.00) | POLBSMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL1156718 | 0.71 | ABL1 (0.58) | POLBSMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL6034118 | 0.71 | PKM (0.58) | POLBSMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL307106 | 0.70 | POLB (0.61) | POLBSMN1; SMN2TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648201-B2 | Aminopyridine derivatives for treating tumors and inflammatory diseases | MERCK PATENT GMBH (DE) | 2014-02-11 | — | — | US | disclosed |