Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | NFATC1 | O95644 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15468467 | 0.83 | SLC22A12 (0.44) | MAPTRPS6KA3SLC22A12KDRMAPK14 | |
| SCHEMBL20020113 | 0.83 | SLC22A12 (0.44) | LMNAMAPTRPS6KA3GSK3BSLC22A12 | |
| SCHEMBL20020060 | 0.83 | RPS6KA3 (0.68) | RPS6KA3SLC22A12CYP3A4 | |
| SCHEMBL16938695 | 0.78 | MAPT (0.55) | LMNAMAPTRPS6KA3CYP1A2CYP2D6 | |
| SCHEMBL15468459 | 0.78 | RPS6KA3 (0.39) | MAPTRPS6KA3SLC22A12CYP3A4KIF11 | |
| SCHEMBL20358436 | 0.77 | RPS6KA3 (0.67) | LMNAMAPTRPS6KA3GSK3BDYRK1A | |
| SCHEMBL25628028 | 0.76 | NOTUM (0.50) | LMNAMAPTRPS6KA3GSK3BNOTUM | |
| SCHEMBL15468462 | 0.72 | SLC22A12 (0.57) | MAPTSLC22A12CYP3A4 | |
| SCHEMBL29157896 | 0.71 | GAA (0.48) | LMNAMAPTRPS6KA3GSK3BDYRK1A | |
| SCHEMBL19961559 | 0.71 | GSK3B (0.47) | LMNAMAPTRPS6KA3GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975025-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Ardea Biosciences, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2712861-B1 | Thioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES INC (US) | 2015-07-29 | — | — | EP | disclosed |
| EP-2585437-B1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC (US) | 2014-02-12 | — | — | EP | disclosed |