Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.68 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15468461 | 0.83 | LMNA (0.46) | RPS6KA3SLC22A12CYP3A4 | |
| SCHEMBL20020113 | 0.80 | SLC22A12 (0.44) | RPS6KA3SLC22A12CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL15468467 | 0.80 | SLC22A12 (0.44) | RPS6KA3SLC22A12 | |
| SCHEMBL30494180 | 0.76 | RPS6KA3 (0.68) | RPS6KA3SLC22A12CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL11258140 | 0.76 | RPS6KA3 (0.68) | RPS6KA3SLC22A12CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL16938695 | 0.76 | MAPT (0.55) | RPS6KA3SLC22A12CYP3A4 | |
| SCHEMBL15468459 | 0.76 | RPS6KA3 (0.39) | RPS6KA3SLC22A12CYP17A1CYP3A4 | |
| SCHEMBL29153269 | 0.73 | RPS6KA3 (0.70) | RPS6KA3SLC22A12CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL19955351 | 0.73 | RPS6KA3 (0.63) | RPS6KA3SLC22A12CYP19A1CYP11B2ESR1 | |
| SCHEMBL15468462 | 0.73 | SLC22A12 (0.57) | SLC22A12CYP3A4MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975025-B1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |