Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15468461 | 0.83 | LMNA (0.46) | SLC22A12RPS6KA3MAPK14MAPTKDR | |
| SCHEMBL28279885 | 0.81 | RPS6KA3 (0.63) | SLC22A12RPS6KA3GCGRNPC1RAB9A | |
| SCHEMBL20020060 | 0.80 | RPS6KA3 (0.68) | SLC22A12RPS6KA3 | |
| SCHEMBL20020113 | 0.80 | SLC22A12 (0.44) | SLC22A12RPS6KA3GCGRNPC1RAB9A | |
| SCHEMBL24810003 | 0.76 | SLC22A12 (0.44) | SLC22A12RPS6KA3GCGRNPC1RAB9A | |
| SCHEMBL28109293 | 0.76 | CYP11B1 (0.50) | SLC22A12RPS6KA3GCGRMAPK14PTGS2 | |
| SCHEMBL15468459 | 0.76 | RPS6KA3 (0.39) | SLC22A12RPS6KA3SMN1; SMN2KDM4EMAPT | |
| SCHEMBL16938695 | 0.76 | MAPT (0.55) | SLC22A12RPS6KA3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30851299 | 0.73 | SLC22A12 (0.42) | SLC22A12RPS6KA3GCGRNPC1RAB9A | |
| SCHEMBL30851377 | 0.73 | CYP11B2 (0.54) | SLC22A12RPS6KA3GCGRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975025-A1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Ardea Biosciences, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2712861-B1 | Thioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES INC (US) | 2015-07-29 | — | — | EP | disclosed |
| EP-2585437-B1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC (US) | 2014-02-12 | — | — | EP | disclosed |