Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15468459 | 0.79 | RPS6KA3 (0.39) | SLC22A12SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL28879472 | 0.78 | SLC22A12 (0.56) | SLC22A12HTTSMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL29132450 | 0.78 | SMN1; SMN2 (0.60) | HTTSMN1; SMN2L3MBTL1KMT2AMEN1 | |
| SCHEMBL3728246 | 0.77 | SMN1; SMN2 (0.76) | HTTSMN1; SMN2L3MBTL1TSHRMAPK10 | |
| SCHEMBL15158977 | 0.73 | SLC22A12 (1.00) | SLC22A12 | |
| SCHEMBL20020060 | 0.73 | RPS6KA3 (0.68) | SLC22A12MAPK10CYP3A4 | |
| SCHEMBL11192637 | 0.73 | NPC1 (0.65) | HTTSMN1; SMN2L3MBTL1KMT2AKDM4E | |
| SCHEMBL29611891 | 0.73 | NPC1 (0.65) | HTTSMN1; SMN2L3MBTL1KMT2AKDM4E | |
| SCHEMBL526972 | 0.72 | POLB (0.60) | L3MBTL1KMT2AMEN1KDM4EGAA | |
| SCHEMBL15468461 | 0.72 | LMNA (0.46) | SLC22A12MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585437-B1 | THIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC (US) | 2014-02-12 | — | — | EP | disclosed |