Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | DGKA | P23743 | 1/20 | 0.51 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL15475722 | 1.00 | DNM1 (0.62) | DNM1RAD52NPSR1DGKASLC25A20 | |
| Glycinebetaine SCHEMBL15475765 | 1.00 | DNM1 (0.62) | DNM1RAD52NPSR1DGKASLC25A20 | |
| Glycinebetaine SCHEMBL4653512 | 0.86 | DGKA (0.61) | DNM1RAD52NPSR1DGKASLC25A20 | |
| SCHEMBL6849042 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT | |
| SCHEMBL13923753 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT | |
| SCHEMBL4322849 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT | |
| SCHEMBL10622058 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT | |
| SCHEMBL8397714 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT | |
| SCHEMBL8398143 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT | |
| SCHEMBL4325848 | 0.86 | DNM1 (0.83) | DNM1DGKATSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140050687-A1 | BETAINE ESTERS AND PROCESS FOR MAKING AND USING | ESTMAN CHEMICAL COMPANY (US) | 2014-02-20 | — | — | US | claimed |
| US-9487805-B2 | Betaine esters and process for making and using | EASTMAN CHEMICAL COMPANY (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150376662-A1 | BETAINE ESTERS AND PROCESS FOR MAKING AND USING | EASTMAN CHEMICAL COMPANY (US) | 2015-12-31 | — | — | US | disclosed |
| US-20140050687-A1 | BETAINE ESTERS AND PROCESS FOR MAKING AND USING | ESTMAN CHEMICAL COMPANY (US) | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140050687-A1 | BETAINE ESTERS AND PROCESS FOR MAKING AND USING | SLC6A12, BCHE, COASY | DNM1 3234/4885RAD52 3202/4885NPSR1 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.