Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.58 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.47 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388962 | 0.87 | CHKA (0.57) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL14708808 | 0.82 | CHKA (0.52) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL3454549 | 0.82 | KCNH2 (0.60) | CHKAFERMT2NR4A2LMNAKDM4E | |
| SCHEMBL14698794 | 0.81 | CHKA (0.51) | CHKAFERMT2NR4A2SOS2LMNA | |
| Hydrochloric Acid SCHEMBL15476175 | 0.81 | CHKA (0.51) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL30058586 | 0.81 | CHKA (0.68) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL1706258 | 0.81 | CHKA (0.68) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL18281201 | 0.80 | FERMT2 (0.54) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL17834978 | 0.80 | CHKA (0.50) | CHKAFERMT2NR4A2SOS2LMNA | |
| SCHEMBL18281263 | 0.79 | CHKA (0.54) | CHKAFERMT2NR4A2SOS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140050696-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2014-02-20 | — | — | US | claimed |
| US-20170166530-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-06-15 | — | — | US | disclosed |
| US-20160168099-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168099-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-06-16 | — | — | US | disclosed |
| US-20140050696-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168099-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | UACA, SQSTM1, ATG7 | CHKA 906/4885FERMT2 4433/4885NR4A2 4610/4885 |
| US-20140050696-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | UACA, SQSTM1, ATG7 | CHKA 906/4885FERMT2 4433/4885NR4A2 4610/4885 |
| US-20170166530-A1 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE | UACA, SQSTM1, ATG7 | CHKA 906/4885FERMT2 4433/4885NR4A2 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.