SCHEMBL1706258

SCHEMBL1706258

CN(C)c1ccnc2cc(Cl)ccc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHKA P35790 2/20 0.68
NR4A2 P43354 3/20 0.56
SOS2 Q07890 1/20 0.56
LMNA P02545 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
FERMT2 Q96AC1 2/20 0.50
CYP1A2 P05177 1/20 0.50
HSD17B10 Q99714 2/20 0.47
MAPT P10636 2/20 0.47
KMT2A Q03164 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
CCR1 P32246 1/20 0.47
PKM P14618 1/20 0.47
ALOX15 P16050 1/20 0.47
CASP1 P29466 1/20 0.47
KDM4E B2RXH2 1/20 0.47
HTT P42858 1/20 0.47
TLR8 Q9NR97 1/20 0.46
MEN1 O00255 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30058586 1.00 CHKA (0.68) CHKANR4A2SOS2LMNASMN1; SMN2
Hydrochloric Acid SCHEMBL10573768 0.85 CHKA (0.62) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL2219585 0.83 CHKA (0.83) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL11136934 0.81 CHKA (1.00) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL15475876 0.81 CHKA (0.58) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL10062533 0.80 CHKA (0.77) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL10403382 0.80 CHKA (0.60) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL6388962 0.80 CHKA (0.57) CHKANR4A2SOS2LMNASMN1; SMN2
SCHEMBL7498608 0.79 CHKA (0.75) CHKANR4A2SOS2LMNASMN1; SMN2
Hydrochloric Acid SCHEMBL10403769 0.79 CHKA (0.59) CHKANR4A2SOS2LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4076459-B1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-04-29 EP disclosed
US-12595248-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2026-04-07 US disclosed
EP-4076460-B1 1,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-3,4'-PIPERIDINE DERIVATIVES AS PRMT5 INHIBITORS FOR THE TREATMENT OF CANCER MERCK SHARP & DOHME LLC (US) 2026-01-21 EP disclosed
US-12441730-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2025-10-14 US disclosed
EP-3521283-B1 COMPOUNDS USEFUL FOR TREATING CANCER ABIVAX (FR) 2024-02-28 EP disclosed
EP-3517534-B1 COMPOUNDS USEFUL FOR TREATING CANCER ABIVAX (FR) 2024-02-28 EP disclosed
US-20230114091-A1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2023-04-13 US disclosed
US-20230108114-A1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2023-04-06 US disclosed
US-20220127253-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING ABIVAX (FR) 2022-04-28 US disclosed
WO-2021126729-A1 PRMT5 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2021-06-24 WO disclosed
US-20180339981-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING ABIVAX (FR) 2018-11-29 US disclosed
US-20170226095-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING ABIVAX (FR) 2017-08-10 US disclosed
US-9637475-B2 Compounds for treating cancer ABIVAX (FR) 2017-05-02 US disclosed
WO-2016193503-A2 ANALOGUES OF HYDROXYCHLOROQUINE (HCQ) WITHOUT RETINAL TOXICITY INOVIEM SCIENTIFIC (FR) 2016-12-08 WO disclosed
US-20150299129-A1 COMPOUNDS FOR TREATING CANCER UNIVERSITE DE MONTPELLIER (FR) 2015-10-22 US disclosed
US-9108919-B2 Compounds useful for treating cancer ABIVAX (FR) 2015-08-18 US disclosed
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE (FR) 2014-03-20 US disclosed
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER SOCIETE SPLICOS (FR) 2012-11-01 US disclosed
EP-2440545-A2 COMPOUNDS USEFUL FOR TREATING CANCER Société Splicos (FR) 2012-04-18 EP disclosed
WO-2010143168-A2 COMPOUNDS USEFUL FOR TREATING CANCER SOCIÉTÉ SPLICOS (FR) 2010-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170226095-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING RCOR1, NR3C1, NR5A1 CHKA 3601/4885NR4A2 72/4885SOS2 4346/4885
US-20230114091-A1 PRMT5 INHIBITORS PRMT5, PRMT1, PRMT3 CHKA 2378/4885NR4A2 3706/4885SOS2 4262/4885
US-12595248-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT6 CHKA 927/4885NR4A2 1321/4885SOS2 1857/4885
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER CBR1, CBR3, NCOR1 CHKA 2695/4885NR4A2 22/4885SOS2 2820/4885
US-20150299129-A1 COMPOUNDS FOR TREATING CANCER NR1H4, NR1H3, NCOR1 CHKA 3301/4885NR4A2 34/4885SOS2 3992/4885
US-20220127253-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING RCOR1, NR3C1, NR5A1 CHKA 3601/4885NR4A2 72/4885SOS2 4346/4885
US-20180339981-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING RCOR1, NR3C1, NR5A1 CHKA 3601/4885NR4A2 72/4885SOS2 4346/4885
US-12441730-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT3 CHKA 2378/4885NR4A2 3706/4885SOS2 4262/4885
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER NR1H4, NR1H3, NCOR1 CHKA 3136/4885NR4A2 41/4885SOS2 3669/4885
US-20230108114-A1 PRMT5 INHIBITORS PRMT5, PRMT1, PRMT3 CHKA 2228/4885NR4A2 3559/4885SOS2 4371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.