Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480653

SCHEMBL15480653

SCHEMBL15480653

CN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccc(C(=O)NO)cc1

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 2/20 0.52
▸ MEN1 O00255 3/20 0.50
▸ KMT2A Q03164 3/20 0.50
▸ POLB P06746 2/20 0.50
▸ HDAC6 Q9UBN7 3/20 0.49
▸ HDAC1 Q13547 3/20 0.49
▸ RAB9A P51151 3/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ GFER P55789 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ LMNA P02545 1/20 0.46
▸ HDAC8 Q9BY41 1/20 0.46
▸ MAPT P10636 2/20 0.46
▸ NPC1 O15118 2/20 0.46
▸ MITF O75030 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31155755 0.85 ATM (0.57) ATMRAB9AL3MBTL1GFERALDH1A1
SCHEMBL7375263 0.84 ACHE (0.56) ATMMEN1KMT2APOLBALDH1A1
SCHEMBL296991 0.83 MEN1 (0.68) MEN1KMT2APOLBHDAC6HDAC1
SCHEMBL7376913 0.82 ATM (0.55) ATMMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL7379932 0.82 ATM (0.75) ATMMEN1KMT2APOLBRAB9A
SCHEMBL15480654 0.82 HDAC6 (0.72) POLBHDAC6HDAC1ALDH1A1HDAC8
SCHEMBL4659080 0.80 HDAC6 (0.67) HDAC6HDAC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL4659287 0.80 HDAC6 (0.67) HDAC6HDAC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL15480652 0.80 HDAC6 (0.56) KMT2AHDAC6HDAC1RAB9AHDAC8
SCHEMBL4610487 0.80 HDAC1 (0.61) KMT2AHDAC6HDAC1RAB9AHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 ATM 2870/4885MEN1 4342/4885KMT2A 223/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 ATM 2870/4885MEN1 4342/4885KMT2A 223/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 ATM 2870/4885MEN1 4342/4885KMT2A 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.