Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480875

SCHEMBL15480875

SCHEMBL15480875

O=C(O)c1ncc(Br)cc1C(F)F

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ POLB P06746 1/20 0.39
▸ HCAR2 Q8TDS4 1/20 0.39
▸ BACE1 P56817 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ DYRK1B Q9Y463 1/20 0.33
▸ HTT P42858 2/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ ABHD6 Q9BV23 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ HDAC8 Q9BY41 1/20 0.30
▸ OPRK1 P41145 1/20 0.30
▸ ASPH Q12797 2/20 0.30
▸ KDM8 Q8N371 2/20 0.30
▸ DAO P14920 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28781092 0.81 ALDH1A1 (0.38) KDM4EALDH1A1POLBHCAR2SMN1; SMN2
SCHEMBL16095860 0.80 OPRK1 (0.38) BACE1HTTOPRK1
SCHEMBL23580970 0.80 HTT (0.35) ALDH1A1BACE1SMN1; SMN2HTTOPRK1
SCHEMBL16095081 0.78 LRRK2 (0.43) BACE1HTT
SCHEMBL29882613 0.78 ALDH1A1 (0.40) KDM4EALDH1A1BACE1ABHD6KMT2A
SCHEMBL15480878 0.78 ALDH1A1 (0.40) KDM4EALDH1A1BACE1ABHD6KMT2A
SCHEMBL29882240 0.77 ALDH1A1 (0.41) ALDH1A1POLBBACE1ABHD6
SCHEMBL23608896 0.77 ALDH1A1 (0.41) ALDH1A1POLBBACE1ABHD6
SCHEMBL23580498 0.76 ALDH1A1 (0.32) ALDH1A1BACE1SMN1; SMN2HTTKMT2A
SCHEMBL1661495 0.76 KDM4E (0.42) KDM4EALDH1A1POLBHCAR2BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250136577-A1 HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS C4X DISCOVERY LIMITED (GB) 2025-05-01 — — US disclosed
CN-114945571-B Cyclic compounds and methods of use thereof 薛定谔公司 2025-02-25 — — CN disclosed
EP-4472734-A1 HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS C4X Discovery Limited (GB) 2024-12-11 — — EP disclosed
CN-119095837-A Heterocyclic derivatives as MALT1 inhibitors 希四克斯探索有限公司 2024-12-06 — — CN disclosed
US-20240018157-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME SCHRÖDINGER, INC. 2024-01-18 — — US disclosed
US-20240018157-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME SCHRÖDINGER, INC. 2024-01-18 — — US disclosed
WO-2023148501-A1 HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS C4X DISCOVERY LIMITED (GB) 2023-08-10 — — WO disclosed
EP-4081526-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME Schrödinger, Inc. (US) 2022-11-02 — — EP disclosed
CN-114945571-A Cyclic compounds and methods of use thereof 薛定谔公司 2022-08-26 — — CN disclosed
WO-2021134004-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME SCHRODINGER, INC. (US) 2021-07-01 — — WO disclosed
US-9085576-B2 Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use AMGEN INC. (US) 2015-07-21 — — US disclosed
US-9085576-B2 Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use AMGEN INC. (US) 2015-07-21 — — US disclosed
US-8883779-B2 Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them SHINOGI & CO., LTD. (JP) 2014-11-11 — — US disclosed
US-8883779-B2 Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them SHINOGI & CO., LTD. (JP) 2014-11-11 — — US disclosed
US-20140275058-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. 2014-09-18 — — US disclosed
US-20140275058-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. 2014-09-18 — — US disclosed
WO-2014138484-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2014-09-12 — — WO disclosed
EP-2703399-A1 OXAZINE DERIVATIVE AND BACE 1 INHIBITOR CONTAINING SAME Shionogi & Co., Ltd. (JP) 2014-03-05 — — EP disclosed
US-20140051691-A1 OXAZINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION FOR INHIBITING BACE1 CONTAINING THEM SHIONOGI & CO., LTD. (JP) 2014-02-20 — — US disclosed
US-20140051691-A1 OXAZINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION FOR INHIBITING BACE1 CONTAINING THEM SHIONOGI & CO., LTD. (JP) 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250136577-A1 HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS MALT1, SQSTM1, FKBP1A KDM4E 1395/4885ALDH1A1 1855/4885POLB 4662/4885
US-20140275058-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE BACE1, BACE2, APP KDM4E 2749/4885ALDH1A1 317/4885POLB 1081/4885
US-20140051691-A1 OXAZINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION FOR INHIBITING BACE1 CONTAINING THEM BACE1, BACE2, APP KDM4E 2189/4885ALDH1A1 3136/4885POLB 1130/4885
US-20240018157-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME MALT1, FKBP1B, FKBP1A KDM4E 3357/4885ALDH1A1 2190/4885POLB 4303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.