SCHEMBL1551082

SCHEMBL1551082

O=c1cccc2[nH]cccc1-2

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AURKA O14965 3/20 0.53
KDR P35968 3/20 0.53
CDK2 P24941 4/20 0.39
PARP1 P09874 1/20 0.39
AURKB Q96GD4 2/20 0.37
DAO P14920 1/20 0.37
INCENP Q9NQS7 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
FKBP5 Q13451 1/20 0.36
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
CHEK1 O14757 2/20 0.34
WEE1 P30291 1/20 0.34
MCL1 Q07820 1/20 0.33
NAPRT Q6XQN6 1/20 0.33
ADRA1D P25100 1/20 0.33
ADRA1A P35348 1/20 0.33
ADRA1B P35368 1/20 0.33
CSF1R P07333 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4430517 0.98 AURKA (0.51) AURKAKDRCDK2PARP1AURKB
Hydrochloric Acid SCHEMBL4436439 0.98 AURKA (0.51) AURKAKDRCDK2PARP1AURKB
SCHEMBL15416821 0.78 KDR (0.47) AURKAKDRCDK2PARP1AURKB
SCHEMBL10702785 0.74 AURKA (0.42) AURKAKDRMEN1KMT2AADRA1A
SCHEMBL6706494 0.74 AURKA (0.54) AURKAKDRCDK2MEN1KMT2A
SCHEMBL30775288 0.72 KDR (0.61) AURKAKDRPARP1LTKCSNK1A1
SCHEMBL9806074 0.72 IDO1 (0.40) AURKAKDRCDK2AURKBDAO
SCHEMBL31408898 0.72 AURKA (0.42) AURKAKDRCDK2AURKBDAO
SCHEMBL630634 0.71 HDAC6 (0.41) AURKAKDRCDK2PARP1AURKB
SCHEMBL6425215 0.70 AURKA (0.43) AURKAKDRCDK2PARP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025120200-A1 NEW ANTI-INFECTIVE TRICYCLIC SPIROLACTAMS COMPOUNDS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 2025-06-12 WO claimed
CN-119350239-A 5-Quinoline penta-2, 4-diene amide derivative and preparation method and application thereof 常熟理工学院 2025-01-24 CN claimed
CN-114891011-B Preparation method of medical intermediate 2-amino-tetrahydropyran [3,2-c ] quinoline-5-one derivative 南京苏亦欣医药科技有限公司 2025-01-17 CN claimed
CN-118530732-A Isothiocyanate liquid crystal material and application thereof 华为技术有限公司 2024-08-23 CN claimed
CN-118530733-A Heterocyclic liquid crystal material and application thereof 华为技术有限公司 2024-08-23 CN claimed
EP-4392425-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF Impact Therapeutics (Shanghai), Inc. (CN) 2024-07-03 EP claimed
WO-2023025307-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) 2023-03-02 WO claimed
EP-2125813-A2 COMPOUNDS Glaxo Group Limited (GB) 2009-12-02 EP claimed
CN-100475207-C 1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases NOVARTIS AG (CH) 2009-04-08 CN claimed
WO-2008116815-A2 COMPOUNDS GLAXO GROUP LIMITED (GB) 2008-10-02 WO claimed
EP-1692138-A1 PYRANO-QUINOLINES, PYRANO-QUINOLINONES, COMBINATIONS THEREOF, PHOTOCHROMIC COMPOSITIONS AND ARTICLES TRANSITIONS OPTICAL, INC. (US) 2006-08-23 EP claimed
CN-1655788-A 1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases NOVARTIS AG (CH) 2005-08-17 CN claimed
WO-2005061514-A1 PYRANO-QUINOLINES, PYRANO-QUINOLINONES, COMBINATIONS THEREOF, PHOTOCHROMIC COMPOSITIONS AND ARTICLES TRANSITIONS OPTICAL, INC. (US) 2005-07-07 WO claimed
CN-1093860-C Pyridazino [4, 5-b ] quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists MERZ & CO GMBH & CO (DE) 2002-11-06 CN claimed
EP-1194429-A1 POTASSIUM CHANNEL OPENERS Abbott Laboratories (US) 2002-04-10 EP claimed
WO-2000078768-A1 POTASSIUM CHANNEL OPENERS ABBOTT LABORATORIES (US) 2000-12-28 WO claimed
EP-1040097-A1 POTASSIUM CHANNEL OPENERS Abbott Laboratories (US) 2000-10-04 EP claimed
CN-1228778-A Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists MERZ & CO GMBH & CO (DE) 1999-09-15 CN claimed
WO-1999031059-A1 POTASSIUM CHANNEL OPENERS ABBOTT LABORATORIES (US) 1999-06-24 WO claimed
WO-2025120200-A1 NEW ANTI-INFECTIVE TRICYCLIC SPIROLACTAMS COMPOUNDS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 2025-06-12 WO disclosed
EP-4543437-A1 3-?HSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF THE CLEVELAND CLINIC FOUNDATION (US) 2025-04-30 EP disclosed
CN-119569751-A Compound, liquid crystal composition and application thereof 华为技术有限公司 2025-03-07 CN disclosed
CN-119350239-A 5-Quinoline penta-2, 4-diene amide derivative and preparation method and application thereof 常熟理工学院 2025-01-24 CN disclosed
CN-114891011-B Preparation method of medical intermediate 2-amino-tetrahydropyran [3,2-c ] quinoline-5-one derivative 南京苏亦欣医药科技有限公司 2025-01-17 CN disclosed
CN-119176798-A Dihydropyrimidinone-coumarin derivative and preparation method thereof 宜春学院 2024-12-24 CN disclosed
CN-118530732-A Isothiocyanate liquid crystal material and application thereof 华为技术有限公司 2024-08-23 CN disclosed
CN-118530733-A Heterocyclic liquid crystal material and application thereof 华为技术有限公司 2024-08-23 CN disclosed
CN-118451068-A Tri-fused ring derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-08-06 CN disclosed
EP-4392425-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF Impact Therapeutics (Shanghai), Inc. (CN) 2024-07-03 EP disclosed
CN-113677680-B EGFR inhibitor, composition and application thereof 贝达药业股份有限公司 2024-05-10 CN disclosed
EP-4326726-A2 METHODS, KITS AND COMPOSITIONS FOR REDUCING CHROMOSOMAL INSTABILITY IN CANCER CELLS Baruch S. Blumberg Institute (US) 2024-02-28 EP disclosed
WO-2023250480-A1 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF THE CLEVELAND CLINIC FOUNDATION (US) 2023-12-28 WO disclosed
CN-117295733-A Immunomodulator and immunomodulator conjugates 明尼苏达大学董事会 2023-12-26 CN disclosed
WO-2023107371-A1 SOLID FORMS OF RESIQUIMOD AND FORMULATIONS THEREOF SURGE Therapeutics, Inc. (US) 2023-06-15 WO disclosed
WO-2023025307-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) 2023-03-02 WO disclosed
CN-115087486-A Substituted bicyclic and tricyclic ureas and amides, analogs thereof, and methods of use thereof 爱彼特生物制药公司 2022-09-20 CN disclosed
CN-114891011-A Preparation method of medical intermediate 2-amino-tetrahydropyrano [3, 2-c ] quinoline-5-ketone derivative 南京苏亦欣医药科技有限公司 2022-08-12 CN disclosed
US-20220133740-A1 VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS Frequency Therapeutics, Inc. (US) 2022-05-05 US disclosed
CN-109071535-B NLRP3 modulators 先天肿瘤免疫公司 2021-10-08 CN disclosed
EP-3887478-A1 COMPOUNDS FOR ELECTRONIC DEVICES Merck Patent GmbH (DE) 2021-10-06 EP disclosed
CN-113166639-A Compounds for electronic devices 默克专利有限公司 2021-07-23 CN disclosed
WO-2020125403-A1 PHARMACEUTICAL COMPOSITION 江苏先声药业有限公司 2020-06-25 WO disclosed
CN-110325534-A Substituted imidazoquinolines as NLRP3 modulators 先天肿瘤免疫公司 2019-10-11 CN disclosed
EP-3510034-A1 SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS Innate Tumor Immunity, Inc. (US) 2019-07-17 EP disclosed
WO-2018152396-A1 SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS INNATE TUMOR IMMUNITY, INC. (US) 2018-08-23 WO disclosed
CN-108250142-A Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity 维尔斯达医疗公司 2018-07-06 CN disclosed
EP-3331581-A1 MECHANOPHORIC MEDICAL PRODUCT Aesculap AG (DE) 2018-06-13 EP disclosed
CN-108137586-A novel imidazo [4,5-c ] quinoline and imidazo [4,5-c ] [1,5] naphthyridine derivatives as L RRK2 inhibitors 辉瑞大药厂 2018-06-08 CN disclosed
CN-104968200-B Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity 维尔斯达医疗公司 2018-03-06 CN disclosed
WO-2016186453-A1 QUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS KAINOS MEDICINE, INC. (KR) 2016-11-24 WO disclosed
CN-104968200-A Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity WELLSTAT THERAPEUTICS CORP 2015-10-07 CN disclosed
CN-103038217-A Novel microbiocidal dioxime ether derivatives SYNGENTA PARTICIPATIONS AG 2013-04-10 CN disclosed
CN-102592040-A Drug discovery method KEDDEM BIO SCIENCE LTD 2012-07-18 CN disclosed
CN-101410114-B A3 adenosine receptor allosteric modulators US GOV HEALTH & HUMAN SERV (US) 2012-07-04 CN disclosed
US-20110178106-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF SOUTHERN RESEARCH INSTITUTE OFFICE OF COMMERCIALIZ (US) 2011-07-21 US disclosed
US-20110178106-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF SOUTHERN RESEARCH INSTITUTE OFFICE OF COMMERCIALIZ (US) 2011-07-21 US disclosed
CN-102088852-A 5-quinolinone and imidazopyridine compounds and use thereof SOUTHERN RES INST 2011-06-08 CN disclosed
CN-102088852-A 5-quinolinone and imidazopyridine compounds and use thereof SOUTHERN RES INST 2011-06-08 CN disclosed
CN-102088852-A 5-quinolinone and imidazopyridine compounds and use thereof SOUTHERN RES INST 2011-06-08 CN disclosed
EP-2312948-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF Southern Research Institute (US) 2011-04-27 EP disclosed
EP-2312948-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF Southern Research Institute (US) 2011-04-27 EP disclosed
WO-2010006251-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF SOUTHERN RESEARCH INSTITUTE (US) 2010-01-14 WO disclosed
WO-2010006251-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF SOUTHERN RESEARCH INSTITUTE (US) 2010-01-14 WO disclosed
EP-2125813-A2 COMPOUNDS Glaxo Group Limited (GB) 2009-12-02 EP disclosed
EP-1819676-A4 5-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2009-04-15 EP disclosed
CN-101410114-A A3 adenosine receptor allosteric modulators US GOV HEALTH & HUMAN SERV (US) 2009-04-15 CN disclosed
CN-100475207-C 1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases NOVARTIS AG (CH) 2009-04-08 CN disclosed
WO-2008116815-A2 COMPOUNDS GLAXO GROUP LIMITED (GB) 2008-10-02 WO disclosed
US-20080009518-A1 5-Phenyl-5,6,7,8-Hydroquinoline Tachykinin Receptor Antagonists MERCK SHARP & DOHME CORP. 2008-01-10 US disclosed
EP-1819676-A2 5-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2007-08-22 EP disclosed
WO-2007026371-A2 PROCESS FOR PREPARING TRANDOLAPRIL AND INTERMEDIATES THEREOF WOCKHARDT LIMITED (IN) 2007-03-08 WO disclosed
CN-1914203-A Sulfone substituted imidazo ring ethers 3M INNOVATIVE PROPERTIES CO (US) 2007-02-14 CN disclosed
EP-1694674-A2 SULFONE SUBSTITUTED IMIDAZO RING ETHERS 3M Innovative Properties Company (US) 2006-08-30 EP disclosed
EP-1692138-A1 PYRANO-QUINOLINES, PYRANO-QUINOLINONES, COMBINATIONS THEREOF, PHOTOCHROMIC COMPOSITIONS AND ARTICLES TRANSITIONS OPTICAL, INC. (US) 2006-08-23 EP disclosed
WO-2006060344-A2 5-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 2006-06-08 WO disclosed
CN-1747953-A Aryl / hetaryl substituted imidazoquinolines. 3M INNOVATIVE PROPERTIES CO (US) 2006-03-15 CN disclosed
WO-2005123080-A2 NITROGEN-CONTAINING HETEROCYCLYL SUBSTITUTED IMIDAZOQUINOLINES AND IMIDAZONAPHTHYRIDINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-12-29 WO disclosed
WO-2005076783-A2 SULFONE SUBSTITUTED IMIDAZO RING ETHERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-08-25 WO disclosed
CN-1655788-A 1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases NOVARTIS AG (CH) 2005-08-17 CN disclosed
WO-2005061514-A1 PYRANO-QUINOLINES, PYRANO-QUINOLINONES, COMBINATIONS THEREOF, PHOTOCHROMIC COMPOSITIONS AND ARTICLES TRANSITIONS OPTICAL, INC. (US) 2005-07-07 WO disclosed
CN-1422269-A 1H-imidazopyridine derivatives HOKURIKU PHARMACEUTICAL (JP) 2003-06-04 CN disclosed
CN-1093860-C Pyridazino [4, 5-b ] quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists MERZ & CO GMBH & CO (DE) 2002-11-06 CN disclosed
EP-1194429-A1 POTASSIUM CHANNEL OPENERS Abbott Laboratories (US) 2002-04-10 EP disclosed
EP-0894796-B1 Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists ADIR (FR) 2001-06-06 EP disclosed
WO-2000078768-A1 POTASSIUM CHANNEL OPENERS ABBOTT LABORATORIES (US) 2000-12-28 WO disclosed
EP-1040097-A1 POTASSIUM CHANNEL OPENERS Abbott Laboratories (US) 2000-10-04 EP disclosed
CN-1228778-A Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists MERZ & CO GMBH & CO (DE) 1999-09-15 CN disclosed
WO-1999031059-A1 POTASSIUM CHANNEL OPENERS ABBOTT LABORATORIES (US) 1999-06-24 WO disclosed
EP-0894796-A1 Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists ADIR ET COMPAGNIE (FR) 1999-02-03 EP disclosed
EP-0888347-A1 PHARMACEUTICALLY USEFUL COMPOUNDS Astra Pharmaceuticals Limited (GB) 1999-01-07 EP disclosed
EP-0489379-B1 5-amino-5,6,7,8-tetrahydroquinolines and related compounds, a process for their preparation and their use as medicaments HOECHST MARION ROUSSEL INC (US) 1998-07-15 EP disclosed
WO-1997034893-A1 PHARMACEUTICALLY USEFUL COMPOUNDS ASTRA PHARMACEUTICALS LTD. (GB) 1997-09-25 WO disclosed
US-5310914-A Imination, reduction HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1994-05-10 US disclosed
US-5216164-A Used for relieving memory dysfunction such as Alzheimer's disease HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-06-01 US disclosed
EP-0489379-A1 5-amino-5,6,7,8-tetrahydroquinolines and related compounds, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-06-10 EP disclosed
US-5110815-A Alzheimer's disease HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1992-05-05 US disclosed
US-3978079-A DIPHTHALIMIDO, DISUCCINIMIDO AND DIMALEIMIDO OXALATES AMERICAN CYANAMID COMPANY (US) 1976-08-31 US disclosed
US-3970660-A BIS(1,2-DIHYDRO-2-OXO-1-PYRIDYL) GLYOXAL AMERICAN CYANAMID COMPANY (US) 1976-07-20 US disclosed
US-3970660-A BIS(1,2-DIHYDRO-2-OXO-1-PYRIDYL) GLYOXAL AMERICAN CYANAMID COMPANY (US) 1976-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178106-A1 5-QUINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF ABCC5, ABCC1, ABCB1 AURKA 1267/4885KDR 4240/4885CDK2 1589/4885
US-20080009518-A1 5-Phenyl-5,6,7,8-Hydroquinoline Tachykinin Receptor Antagonists TACR1, HTR5A, TACR2 AURKA 1495/4885KDR 1960/4885CDK2 872/4885
US-20220133740-A1 VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS WNT3A, WNT1, WNT3 AURKA 1721/4885KDR 3862/4885CDK2 3018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.