SCHEMBL1551138

SCHEMBL1551138

NS(=O)(=O)c1cccc2cnccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.61
CA2 P00918 2/20 0.61
CA9 Q16790 2/20 0.61
CYP3A4 P08684 6/20 0.60
PRKD3 O94806 5/20 0.60
PRKCG P05129 5/20 0.60
PRKCB P05771 5/20 0.60
PRKCA P17252 5/20 0.60
PRKCH P24723 5/20 0.60
PRKCI P41743 5/20 0.60
PRKCE Q02156 5/20 0.60
PRKCQ Q04759 5/20 0.60
PRKCZ Q05513 5/20 0.60
PRKCD Q05655 5/20 0.60
PRKD1 Q15139 5/20 0.60
CYP2D6 P10635 5/20 0.60
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
PRKACA P17612 3/20 0.60
PRKACG P22612 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30075444 1.00 CA1 (0.61) CA1CA2CA9CYP3A4PRKD3
Hydrochloric Acid SCHEMBL9483668 0.98 LMNA (0.61) CA1CA2CA9CYP3A4PRKD3
Hydrochloric Acid SCHEMBL29748700 0.98 LMNA (0.61) CA1CA2CA9CYP3A4PRKD3
SCHEMBL31527752 0.98 CA1 (0.59) CA1CA2CA9CYP3A4PRKD3
Ethylenediamine SCHEMBL4696234 0.94 CYP3A4 (0.66) CA1CA2CA9CYP3A4PRKD3
Quinoline SCHEMBL28307727 0.87 CA1 (0.51) CA1CA2CA9CYP3A4PRKD3
SCHEMBL18019196 0.86 CA2 (0.61) CA1CA2CA9CYP3A4PRKD3
SCHEMBL6967362 0.85 CYP3A4 (0.59) CYP3A4PRKD3PRKCGPRKCBPRKCA
SCHEMBL117745 0.82 CYP3A4 (0.56) CYP3A4PRKD3PRKCGPRKCBPRKCA
SCHEMBL13677595 0.82 CYP3A4 (0.58) CYP3A4PRKD3PRKCGPRKCBPRKCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 452 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50313-E1 Musculoskeletal stem cell and medium for inducing differentiation of musculoskeletal stem cell CELLATOZ THERAPEUTICS, INC. (KR) 2025-02-25 US claimed
US-20240287027-A1 PREPARATION METHOD FOR COMPOUND FASUDIL HYDROCHLORIDE EAST CHINA UNIVERSITY OF SCIENCE & TECHNOLOGY (CN) 2024-08-29 US claimed
WO-2024017856-A1 NOVEL ISOQUINOLINONE, PYRROLOPYRIDINONE AND THIENOPYRIDINONE SULFONAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2024-01-25 WO claimed
WO-2022262548-A1 PREPARATION METHOD FOR COMPOUND FASUDIL HYDROCHLORIDE 华东理工大学 2022-12-22 WO claimed
EP-3702445-B1 NOVEL MUSCULOSKELETAL STEM CELL CELLATOZ THERAPEUTICS INC (KR) 2022-12-07 EP claimed
CN-113372329-B Preparation method of fasudil hydrochloride compound 华东理工大学 2022-10-18 CN claimed
EP-3702445-A2 NOVEL MUSCULOSKELETAL STEM CELL Cellatoz Therapeutics, Inc. (KR) 2020-09-02 EP claimed
CN-111225974-A Novel musculoskeletal system stem cells 雪拉托兹治疗株式会社 2020-06-02 CN claimed
EP-3643777-A1 NOVEL MUSCULOSKELETAL STEM CELL AND MEDIUM FOR INDUCING DIFFERENTIATION OF MUSCULOSKELETAL STEM CELL Cellatoz Therapeutics, Inc. (KR) 2020-04-29 EP claimed
US-10576106-B2 Musculoskeletal stem cell and medium for inducing differentiation of musculoskeletal stem cell CELLATOZ THERAPEUTICS, INC. (KR) 2020-03-03 US claimed
EP-0669322-B1 Substituted sulfonamides, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 1999-09-15 EP claimed
WO-1999004775-A9 METHOD OF TREATING DOPAMINERGIC AND GABA-NERGIC DISORDERS ONTOGENY INC (US) 1999-04-29 WO claimed
WO-1999020298-A1 REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 1999-04-29 WO claimed
WO-1999010004-A2 REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 1999-03-04 WO claimed
WO-1999000117-A2 NEUROPROTECTIVE METHODS AND REAGENTS ONTOGENY, INC. (US) 1999-01-07 WO claimed
EP-0526342-B1 Isoquinolin-5yl-sulphonamides, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 1996-12-04 EP claimed
EP-0691852-A1 PRODRUGS WITH ENHANCED PENETRATION INTO CELLS D-PHARM, LTD. (IL) 1996-01-17 EP claimed
EP-0669322-A1 Substituted sulfonamides, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1995-08-30 EP claimed
WO-1994022483-A2 PRODRUGS WITH ENHANCED PENETRATION INTO CELLS D-PHARM, LTD. (IL) 1994-10-13 WO claimed
EP-0526342-A1 Isoquinolin-5yl-sulphonamides, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1993-02-03 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287027-A1 PREPARATION METHOD FOR COMPOUND FASUDIL HYDROCHLORIDE BAD, CASP5, REN CA1 4406/4885CA2 1843/4885CA9 4214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.