Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976089 | 0.84 | SMN1; SMN2 (0.47) | DAOGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3939509 | 0.82 | RPS6KB2 (0.42) | DAOKDM4CHSD17B10PDE10ARPS6KB2 | |
| SCHEMBL8139675 | 0.81 | HSP90AB1 (0.52) | HSP90AB1DAOGAAKDM4EHSD17B10 | |
| SCHEMBL2332944 | 0.81 | HSP90AB1 (0.43) | HSP90AB1GAAHSD17B10CASP1CASP7 | |
| SCHEMBL27942177 | 0.80 | DAO (0.47) | DAOKDM4CKDM4ENPSR1PDE10A | |
| Hydrochloric Acid SCHEMBL27660641 | 0.80 | HSP90AB1 (0.42) | HSP90AB1GAAHSD17B10CASP1CASP7 | |
| SCHEMBL27351557 | 0.80 | HSP90AB1 (0.50) | HSP90AB1DAOGAAKDM4EHSD17B10 | |
| SCHEMBL27660644 | 0.80 | HSP90AB1 (0.42) | HSP90AB1DAOGAAKDM4EHSD17B10 | |
| SCHEMBL2332640 | 0.79 | PARP1 (0.45) | HSP90AB1DAOGAAKDM4EHSD17B10 | |
| SCHEMBL13185510 | 0.79 | GSK3B (0.44) | HSP90AB1DAOGAAHSD17B10RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492411-B2 | 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases | FAES FARMA, S.A. (ES) | 2013-07-23 | — | — | US | disclosed |
| EP-2313382-A1 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES | FAES FARMA, S.A. (ES) | 2011-04-27 | — | — | EP | disclosed |
| US-20100305164-A1 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES | FAES FARMA, S.A. (ES) | 2010-12-02 | — | — | US | disclosed |
| US-7781594-B2 | 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases | FAES FARMA, S.A. (ES) | 2010-08-24 | — | — | US | disclosed |
| WO-2009153226-A1 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES | FAES FARMA, S.A. (ES) | 2009-12-23 | — | — | WO | disclosed |
| US-20090312376-A1 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES | FAES FARMA, S.A. (ES) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312376-A1 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES | IL6, CXCL8, IL1B | HSP90AB1 1760/4885DAO 2269/4885KDM4C 3436/4885 |
| US-20100305164-A1 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES | IL6, CXCL8, IL1B | HSP90AB1 1339/4885DAO 2323/4885KDM4C 3968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.